红菇多糖对小鼠肝脏衰老的抑制效果  

Inhibitory Effect of Russula farinipes Romell Polysaccharide on Mice Liver Senescence

作　　者：魏杰[1] 张潇[1] 张国坤[1] 万冬梅[1] 林景峰 孙淑华 WEI Jie ZHANG Xiao ZHANG Guokun WAN Dongmei LIU Jingfeng SUN Shuhua(School of Life Science, Liaoning University,Shenyang 110036, China Liaoning Xianrendong National Nature Reserve Administration Bureau , Dalian 116407 , China)

机构地区：[1]辽宁大学生命科学院,辽宁沈阳110036 [2]辽宁仙人洞国家级自然保护区管理局,辽宁大连116407

出　　处：《食品科学技术学报》2017年第3期50-54,共5页Journal of Food Science and Technology

基　　金：辽宁仙人洞国家级自然保护区大型真菌资源调查项目;辽宁省教育厅教学研究项目(LYB201611);辽宁省社会科学规划基金资助项目(L15BJY029)

摘　　要：研究红菇多糖对衰老昆明小鼠肝功能衰退的抑制作用。使用D-半乳糖建立衰老模型,并在此期间给予75 mg/L与150 mg/L红菇多糖饮水。8周后断颈处死,检测肝指数、血清和肝组织的谷胱甘肽过氧化物酶、超氧化物歧化酶活性及丙二醛含量,同时对肝组织Ca^(2+)-ATPase活性及形态学进行分析。结果表明,8周内给予红菇多糖150 mg/L饮水时,小鼠肝指数、谷胱甘肽过氧化物酶、超氧化物歧化酶活性得到显著提高,丙二醛含量显著下降,小鼠肝功能衰退得到了显著抑制(p<0.05),肝脏的衰老及损伤也得到了有效抵制。Effects of Russula polysaccharide on mice hepatic insufficiency were investigated in this study. The senile model mice were established by D-galactose and mice were treated by 75 mg/L and 150 mg/L Russula polysaccharide. After 8 weeks, liver index, serum and hepatic GSH- Px, SOD activity, MDA contents, Ca2＋ - ATPase activity and hematoxylin-eosin staining of mice were determined. The results showed that the treatment of 150 mg/L Russula polysaccharide could increase liver index, GSH-Px and SOD activity, and decrease the MDA content, which could inhibit the aging of liver.

关 键 词：红菇多糖 肝脏 抗衰老 

分 类 号：TS201.6[轻工技术与工程—食品科学] R151.3[轻工技术与工程—食品科学与工程]