麦胚蛋白对系统性红斑性狼疮的作用机制及其功能分析  

Mechanism of wheat germ protein on systemic lupus erythematosus and its functional analysis

作　　者：黄继红[1] 纪小国 张业奇[1] 赵祎[1] 

机构地区：[1]河南工业大学生物工程学院,河南郑州450001

出　　处：《发酵科技通讯》2017年第1期20-24,共5页Bulletin of Fermentation Science and Technology

基　　金：河南省国际科技合作与交流项目(152102410032);郑州市国际科技合作与交流项目(141PGJHZ546);河南工业大学谷物资源转化与利用省级重点实验室开放课题(001254)

摘　　要：系统性红斑性狼疮(Systemic lupus erythematosus,SLE)因人体免疫系统失调导致人体自身形成抗体来对抗自身的器官或组织,现有治疗手段都有严重的不良反应.根据麦胚的蛋白质全谱,使用GO功能注释和KEGG代谢途径对潜在的麦胚功能蛋白进行分类与分析,重点剖析了麦胚功能蛋白(组蛋白)对系统性红斑狼疮的作用机制,旨在为研究开发植物源免疫活性蛋白提供思路和方法,同时也为医学、生物学、食品工业方面提供宝贵的新资源.Systemic lupus erythematosus （SLE） is caused by the disorder of immune system of human body forming antibodies against human own organs or tissues, and the current treatments have serious adverse reactions. According to the full spectrum of wheat germ protein, the potential functional protein of wheat germ was classified and analyzed by GO function annotation and KEGG metabolic pathway. The mechanism of wheat germ functional protein （histone） on systemic lupus erythematosus was emphatically analyzed. This provides valuable ideas and methods for the research and development of plant-derived immunologically active proteins, and also provides valuable new resources for medicine, biology and food industries.

关 键 词：麦胚蛋白 代谢通路分析 系统性红斑性狼疮 

分 类 号：R392.1[医药卫生—免疫学]