钯催化不对称氢化反应和氢解反应  

Palladium-Catalyzed Chemo-and Enantioselective Hydrogenation and Hydrogenolysis

作　　者：陈建中[1] 张万斌[1] 

机构地区：[1]上海交通大学化学化工学院,上海200240

出　　处：《应用技术学报》2017年第1期85-88,共4页Journal of Technology

基　　金：国家自然科学基金项目(21232004;21620102003);上海市科委基金项目(14XD1402300;15JC1402200;17ZR1415200)资助

摘　　要：实现了α-酰氧基芳基酮的化学选择性和对映选择性氢化及氢解反应,分别得到重要的手性二醇单酯、简单酮和手性α-酰氧基芳基酮.手性产物经过衍生,可应用于多种具有生物活性的天然产物和药物的合成中.该催化反应的底物与催化剂比例(S/C)可高达5 000~6 000,证明了均相钯催化氢化具有工业应用前景.A palladium catalyzed ehemo- and enantioselective hydrogenation and hydrogenolysis of α- acyloxy ketones for the synthesis of chiral α-acyloxy-l-arylethanols, simple ketones and chiral α-acyloxy ketones, has been realized. The chiral products have the potential to be transformed to various biologically active compounds and chiral drugs. S/C ratios up to 5000-6000 are obtained, and this homogeneous palladium catalyzed asymmetric hydrogenation has good prospects for use in industry.

关 键 词：钯催化 不对称氢化 对映选择性 氢解 α-酰氧基芳基酮 

分 类 号：O621.251[理学—有机化学]