Entry of severe fever with thrombocytopenia syndrome virus  

作　　者：Fei Yuan Aihua Zheng 

机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences [2]State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology,Chinese Academy of Sciences

出　　处：《Virologica Sinica》2017年第1期44-50,共7页中国病毒学（英文版）

基　　金：funded by the National Key Plan for Scientific Research and Development of China (2016YFD0500300);the Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) (XDB11030800);the Natural Science Foundation of China (L1524009)

摘　　要：Severe fever with thrombocytopenia syndrome virus （SFTSV） is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses. The virus particles are internalized into host cell endosomes through the clathrin-dependent pathway, where the low pH activates the fusion of the virus with the cell membrane. With information from studies on other bunyaviruses, herein we will review our knowledge of the entry process of SFTSV.Severe fever with thrombocytopenia syndrome virus(SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain ⅡA. The post-fusion crystal structure of the Gc protein suggests that it is a class Ⅱ membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses. The virus particles are internalized into host cell endosomes through the clathrin-dependent pathway, where the low pH activates the fusion of the virus with the cell membrane. With information from studies on other bunyaviruses, herein we will review our knowledge of the entry process of SFTSV.

关 键 词：severe fever with thrombocytopenia syndrome virus （SFTSV） BUNYAVIRUS ENTRY FUSION RECEPTOR 

分 类 号：R373[医药卫生—病原生物学]