肺腺癌CT及临床特征与EGFR 19号外显子突变的相关性研究  

CT and Clinical Features Associated with Epidermal Growth Factor Receptor Mutation of Exon 19 in Lung Adenocarcinoma

作　　者：史张 宋长恩 施睿峰 杨润红[2] 王馨蕊[1] 张倩雯[1] 余永伟[1] 陆建平[1] 蒋涛[1] 刘崎[1] 

机构地区：[1]第二军医大学附属长海医院放射科,上海200433 [2]延安大学附属医院放射科,陕西716000

出　　处：《临床放射学杂志》2017年第4期490-494,共5页Journal of Clinical Radiology

基　　金：国家自然基金项目(编号:No.81402680;No.81371551);上海长海医院1255科学创新基金项目(编号:CH125541000)

摘　　要：目的评价肺腺癌患者的CT及临床特征与表皮生长因子受体(EGFR)19号外显子突变之间的相关性。方法纳入的581例患者均行CT扫描和EGFR基因检测,所需要定性评估的CT及临床特征共有25个。应用单因素对比分析及Logistic回归模型对EGFR野生型和19号外显子突变型的特征相关性进行分析。P值<0.05为差异有统计学意义。结果 581例患者中,突变型共132例(22.7%),野生型为449例(77.3%)。EFGR19号外显子突变型与较小的肿瘤最大径(OR=0.982)、女性(OR=0.380)、胸膜牵拉(OR=2.093)以及无纤维化(OR=0.288)4个特征有关。结论肺腺癌的某些CT及临床特征与EGFR19号外显子基因突变有相关性。Objective To evaluate the association of CT and clinical features with the exon 19 of EGFR mutations in patients with lung adenocarcinoma. Methods 581 Patients who underwent chest CT scan and were detected for the EGFR gene mutations were included. There are 25 CT and clinical features to make the qualitative evaluation. Statistical analysis was used to assess the association of characterizations between EGFR wild types and EGFR mutations in exon 19. P-values 〈0. 05 were cnsidered significant. Results Of 581 patients, 132 were positive for EGRF mutation in exon 19 （22.7%） ; 449 were EGFR wild types （77.3%）. EGRF mutation in exon 19 was associated with small maximum diameter（28.51±14.07）（ OR = 0. 982）; sex （OR = 0.380）; pleural retraction （OR=2. 093）; absence of fibrosis （OR = 0. 288）. Conclusion This study revealed associations between CT and clinical features and EGFR mutations in exon 19.

关 键 词：体层摄影术 X线计算机 肺腺癌 表皮生长因子受体 基因突变 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]