Protective effect of capsaicin against methyl methanesulphonate induced toxicity in the third instar larvae of transgenic Drosophila melanogaster(hsp70-lacZ)Bg9  

作　　者：Saba Khanam Ambreen Fatima Rahul Smita Jyoti Fahad Ali Falaq Naz Barkha Shakya Yasir Hasan Siddique 

机构地区：[1]Drosophila Transgenic Laboratory,Section of Genetics,Department of Zoology,Faculty of Life Sciences,Aligarh Muslim University,Aligarh,Uttar Pradesh 202002,India

出　　处：《Chinese Journal of Natural Medicines》2017年第4期271-280,共10页中国天然药物（英文版）

摘　　要：Capsaicin(trans-8-methyl-N-vanillyl-6-nonenamide) is the main component in hot peppers, including red chili peppers, alapenos, and habanero, belonging to the genus Capsicum. Capsaicin is a potent antioxidant that interferes with free radical activities. In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate(MMS) induced toxicity in third instar larvae of transgenic Drosophila melanogaster(hsp70-lacZ)Bg^9. The third instar was allowed to feed on the diet having different doses of capsaicin and MMS separately and in combination. The results suggested that the exposure of third instar larvae to the diet having MMS alone showed significant hsp70 expression as well as tissue DNA and oxidative damage, whereas the larvae feed on the diet having MMS and capsaicin showed a decrease in the toxic effects for 48-h of exposure. In conclusion, capsaicin showed a dose-dependent decrease in the toxic effects induced by MMS in the third instar larvae of transgenic Drosophila melanogaster.Capsaicin（trans-8-methyl-N-vanillyl-6-nonenamide） is the main component in hot peppers, including red chili peppers, alapenos, and habanero, belonging to the genus Capsicum. Capsaicin is a potent antioxidant that interferes with free radical activities. In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate（MMS） induced toxicity in third instar larvae of transgenic Drosophila melanogaster（hsp70-lacZ）Bg^9. The third instar was allowed to feed on the diet having different doses of capsaicin and MMS separately and in combination. The results suggested that the exposure of third instar larvae to the diet having MMS alone showed significant hsp70 expression as well as tissue DNA and oxidative damage, whereas the larvae feed on the diet having MMS and capsaicin showed a decrease in the toxic effects for 48-h of exposure. In conclusion, capsaicin showed a dose-dependent decrease in the toxic effects induced by MMS in the third instar larvae of transgenic Drosophila melanogaster.

关 键 词：CAPSAICIN Methyl methanesulphonate Drosophila melanogaster TOXICITY 

分 类 号：R965[医药卫生—药理学]