RNase L遗传改变与肿瘤相关性的研究进展  

Research progress in the relationship between RNase L genetic change and cancer

作　　者：王关杰[1] 孙倩[1] 赵炜明[1] 

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室,150081

出　　处：《国际遗传学杂志》2017年第2期104-107,共4页International Journal of Genetics

摘　　要：RNase L是先天免疫系统中的一个重要作用因子.能够使RNA水解从而抑制细胞蛋白质的合成.近年来,RNase L已被报道在多种肿瘤中存在表达差异,并与这些肿瘤的发生发展密切相关.因此,对于RNase L与肿瘤相关性研究可能为肿瘤的治疗提供新的靶点.本文主要对RNase L的结构与功能以及在遗传病方面的研究进展加以综述.Ribonuclease L （RNase L） plays an important role in the innate immune system.It could inhibit the ability of cellular protein synthesis through catalyzing RNA hydrolysis.Recently,differential expression of RNase L expression has been reported in a wide variety of tumor,and that is closely related with the development of these tumors.Thus,studies on the correlation between tumor and RNase L may provide new targets for tumor therapies.This paper focuses on the research progress of the functions and structure of RNase L and their association with genetic etiology of tumors.

关 键 词：核糖核酸酶L 突变 遗传性疾病 肿瘤 

分 类 号：R446.9[医药卫生—诊断学]