以阳性和阴性症状为主的首发精神分裂症患者血清蛋白因子与认知功能的相关分析  

Association study on serum protein factors and cognitive function in first-episode schizophrenia characterized by positive and negative symptoms

作　　者：戴南[1] 陈鹏[2] 曾勇[1] 李明[1] 熊鹏[1] 徐飞[1] 刘芳[1] 节会锦 储睿 郅晋升 

机构地区：[1]昆明医科大学第一附属医院精神科,昆明650031 [2]苏州市广济医院精神科,苏州215000

出　　处：《中华行为医学与脑科学杂志》2017年第5期416-420,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81360210）;苏州市精神疾病临床医学中心项目（Szzx201509）;苏州市精神疾病临床医学中心青年科技项目（gjyy201703）

摘　　要：目的探讨以阳性或阴性症状为主的首发精神分裂症患者血清蛋白因子浓度与认知功能之间的相关性。方法通过酶联免疫吸附技术（ELISA）分别对4J4例以阳性为主的首发精神分裂症患者（阳性组）、36例以阴性症状为主的首发精神分裂症患者（阴性组）和50名正常对照者（对照组）的血清中的神经营养因子-3（neurotrophin-3，NT-3）、白细胞介素-6（inter]eukin-6，IL-6）和钙结合蛋白（calcium binding protein，S10013）进行检测，应用认知功能成套测验共识版（MCCB）进行认知功能评估。结果阴性组和阳性组NT-3浓度低于对照组[（118．39±37．50）ng／L，（112．55±32．29）ug／L，（141．18±29．67）ng／L]（P〈0．01），阴性组和阳性组IL-6、S10013浓度均高于对照组[（5．74±1．00）ng／L，（5．07±1．17）ng／L，（4．23±0．91）ng／L]，[（132．98±46．71）ng／L，（124．99±43．14）ng／L，（103．63±31．57）ng／L]（P〈0．01）。阴性组IL-6浓度高于阳性组[（5．74±1．00）ng／L，（5．07±1．17）ng／L]（P〈0．05）。阴性组和阳性组MCCB检测中TMT评分高于对照组（P〈0．01），阴性组和阳性组BACSSC、HVLT-R、WMS-ⅢSS、NAB、BVMT-R、CF评分低于对照组（P〈0．01），阴性组和阳性组上述评分比较均差异无统计学意义。阳性组血清IL-6浓度与一般症状评分呈正相关CP〈0．05），血清NT-3浓度与其一般症状评分和PANSS总分呈正相关（P〈0．05），血清蛋白NT3和IL-6浓度与BVMT-R评分呈正相关（P〈0．05）。结论首发精神分裂症患者的部分认知功能障碍与血清蛋白因子浓度存在一定联系，以阳性症状为主和以阴性症状为主的首发精神分裂症可能存在不同的病理机制基础。Objective To investigate the relationship between the serum concentration of IL-6, S10013 ,NT-3 and the cognitive functions in first-episode schizophrenia characterized by positive or negative symptoms. Methods 44 first-episode schizophrenic patients characterized by positive symptoms （ positive group） ,36 first-episode schizophrenic patients characterized by negative symptoms （negative group） and 50 healthy controls （controls） were collected. The serum levels of IL-6, S10013 and NT-3 were measured by en- zyme-linked immunosorbent assay （ELISA）. The systematic evaluation tool-MCCB was applied to assess cog- nitive function in patients and controls. Results NT-3 serum levels in positive or negative groups were lower than those in controls and the differences were significant（ （118.39±37.50） ng/L, （112.55±32.29） ng/L vs （141.18±29.67） ng/L） （P〈0.01）. IL-6 and S100β serum levels in positive or negative groups were higher than those in controls and the differences were statistically significant（ （ 5.74± 1.00） ng/L, （ 5.07± 1.17 ） ng/L vs （ 4.23±0.91 ） ng/L）, （ （ 132.98±46.71 ） ng/L, （124.99±43.14） ng/L vs （ 103.63±31.57 ） ng/L） （P〈0.01）.IL-6 serum levels in the positive group （ （ 5.07± 1.17） ng/L） were lower than those in the negative group （（5.74±0.99） ng/L） and the difference was statistically significant （P〈0.05）. In MCCB test, the TMT scores in patients characterize by positive symptoms or patients characterize by negative symptoms were high- er than those in healthy control group （P〈0.O1）. BACS SC, HVLT-R WMS- m, ss, NAB, BVMT-R, CF in pa- tients characterize by positive symptoms or by negative symptoms were lower than those in healthy control group（P〈0.01）. There were no statistical difference in the MCCB scores between the patients with positive symptoms and negative symptoms. In positive group, there was a positive correlation between the IL-6 serum concentration and the general symptom sc

关 键 词：首发精神分裂症 阴性症状 阳性症状 血清蛋白因子 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]