耐辐射球菌辐射耐受机制的研究进展  

Research Progress on the Radiation-resistant Mechanisms of Deinococcus radiodurans

作　　者：陈晓飞[1] 宁萌[1] 冯菲[1] 向凌云[1] 周伏忠[1] 

机构地区：[1]河南省科学院生物研究所有限责任公司河南省微生物工程重点实验室,郑州450008

出　　处：《生物技术通报》2017年第5期9-18,共10页Biotechnology Bulletin

基　　金：河南省科技开放合作项目(152106000052);河南省重点攻关计划项目(152102210167)

摘　　要：耐辐射球菌(Deinococcus radiodurans,Dr)是迄今为止地球上发现的最具辐射抗性的生物之一,对紫外线、干旱和诱变剂等损伤因子均表现出极强的抗性,备受世界各国科学家的广泛关注。目前关于其抗辐射机理已有大量的文献报道。根据国内外最新的研究成果,从DNA损伤修复机制、抗氧化防御系统、特殊的生存方式及细胞净化系统等方面,对耐辐射球菌辐射抗性机理的研究进行了简单的概述,并对未来Dr耐辐射机制的研究趋势进行了展望,以期为进一步研究该菌的辐射耐受机制奠定基础。Deinococcus radiodurans is one of the most radiation-resistant organisms that was found on the earth, and has very high resistance to UV, drought, and mutagenic agents. D. radiodurans has drawn attentions from scientists around the world, and there are many reports about its radiation-resistant mechanisms. In this paper the recent progresses on radiation-resistant mechanisms of D. radiodurans are summarized from DNA-repair pathway, antioxidative defense system, special survival approaches, and cellular purification system. The development trends and future prospects of radiation-resistant mechanisms of D. radiodurans are also discussed, the aim of this paper is to provide some foundations for further study of radiation-resistant mechanisms of the bacteria.

关 键 词：耐辐射球菌 辐射耐受机制 DNA损伤修复 抗氧化 

分 类 号：Q93[生物学—微生物学]