EGFR在胃黏膜良恶性病变中的表达及其临床意义  

Clinical Value of EGFR in Benign and Malignant Lesions of Gastric Mucosa

作　　者：唐晓梅[1] 柴丽丽[2] 秦娟[1] 王三喜[1] 

机构地区：[1]陕西省宝鸡市人民医院,721000 [2]陕西省西安市中心医院,710003

出　　处：《实用癌症杂志》2017年第7期1099-1100,共2页The Practical Journal of Cancer

摘　　要：目的探讨表皮生长因子受体(EGFR)在胃黏膜良恶性病变中的表达及其临床意义。方法选取96例各类型胃黏膜良恶性病变,通过观察各类型胃黏膜良恶性病变中EGFR表达情况及EGFR表达与临床病例参数的关系,评价表皮生长因子受体(EGFR)在胃黏膜良恶性病变中的临床意义。结果胃炎中EGFR无阳性例数,肠化生EGFR阳性率31.6%,异常增生阳性率42.1%,胃腺癌阳性率58.1%,胃黏膜不同病变程度的EGFR表达阳性率比较,差异具有统计学意义(P<0.05);高分化、中分化、低分化胃腺癌的EGFR阳性率相比,无统计学差异(P>0.05)。EGFR在浆膜浸润中的阳性率明显高于在基层浸润中的阳性率(P<0.05),EGFR在有淋巴结转移患者中的阳性率明显高于无淋巴结转移患者(P<0.05)。结论 EGFR检测可以较为准确地预测胃黏膜良恶性病变程度,对临床治疗胃部病变有指导意义。Objective To discuss the clinical value of EGFR in benign and malignant lesions of gastric macosa. Methods 96 patients with different kinds of benign and malignant lesions of gastric mucosa were selected, the clinical value of EGFR in benign and malignant lesions of gastric mucosa was evaluated by positive number of EGFR expression of benign and malignant lesions of gastric mucosa, the relationship between EGFR expression and clinical parameters. Results There were no positive cases of EGFR expression in gastritis. The positive rate of EGFR was 31.6% in intestinal metaplasia,42.1% in dysplasia,58.1% in gastric cancer. The EGFR expression had statistical significance among different lesions （ P 〈 O. 05 ）. There were no statistical significance in EGFR expression among highly differentiated, moderately differentiated and poorly differentiated. The positive rate of EGFR expression in serosal invasion was higher than that of the basic invasion （ P 〈 0.05）. The positive rate of EGFR expression of lymph node metastasis was significantly higher than that of non lymphatic metastasis （P 〈 0.05 ）. Conclusion EGFR detection could predict the degree of benign and malignant gastric lesions accurately and guide the treatment of gastric lesions.

关 键 词：胃黏膜 良恶性病变 胃癌 EGFR 免疫组化法 

分 类 号：R735.2[医药卫生—肿瘤]