自噬与缺氧缺血性脑损伤  

Autophagy and hypoxic ischemic brain injuries

作　　者：厉永强[1] 付苏[1] 王来[1] 刘彬[1] 石贞玉[1] 邓锦波[1] 

机构地区：[1]河南大学护理学院神经生物研究所,开封475004

出　　处：《生理学报》2017年第3期316-324,共9页Acta Physiologica Sinica

摘　　要：自噬是生物体内高度进化保守的生理机制,包括自噬体形成、自噬体与溶酶体结合以及自噬体降解等过程。生理条件下,自噬主要负责清理细胞内衰老的细胞器及长寿命蛋白,对维持细胞及生物体的自稳状态至关重要。同时,自噬也与许多疾病的发生和发展密切相关,但具体的作用与机制尚不十分明确。以脑卒中为代表的缺氧缺血性脑损伤与自噬的关系是近年来的研究热点,关于自噬在其中的作用与机制尚无定论。本文就自噬在缺氧缺血性脑损伤中的激活、发挥的作用及其机制进行综述,旨在为相关领域的研究提供参考。Autophagy is a highly evolutionarily conserved physiological mechanism of organism, including several stages such as au- tophagosomes formation, the fusion of lysosomes and autophagosomes, and autophagosomes degradation. In physiological conditions, autophagy is responsible for clearing the spoiled organelles and long-lived proteins to maintain the homeostasis of cells and organism. Meanwhile, autophagy is also involved in the formation and development of diseases, but the mechanism has not been confirmed yet. The relationship between autophagy and hypoxic ischemic brain injuries represented by stroke is a research hotpot in recent years, but there is no clear conclusion about autophagy＇s role and mechanism in hypoxic ischemic brain injuries. We reviewed the activation, function and mechanism ofantophagy in hypoxic ischemic brain injuries, in order to provide some perspectives on these researches.

关 键 词：自噬 缺氧缺血 氧化应激 细胞凋亡 

分 类 号：R741[医药卫生—神经病学与精神病学]