盐酸氟桂利嗪预防前庭性偏头痛的临床疗效及对患者眩晕发作强度的影响  

Clinical efficacy of flunarizine hydrochloride on prevention of vestibular migraine and its effect on vertigo intensity in patients

作　　者：李晓娜[1] 李玉杰[1] 于敏[1] 赵春红[1] 朱晓凤[1] 范凯慧[1] 

机构地区：[1]郑州大学附属郑州中心医院耳鼻咽喉头颈外科,郑州450007

出　　处：《医药论坛杂志》2017年第6期22-24,共3页Journal of Medical Forum

摘　　要：目的探究盐酸氟桂利嗪应用于前庭性偏头痛(VM)预防中的效果及对患者眩晕发作强度的影响。方法选取郑州大学附属郑州中心医院收治的58例VM患者,依据治疗方法不同分为对照组与研究组,各29例。两组均于眩晕发作时予以甲磺酸倍他司汀片,于此基础上,研究组予以盐酸氟桂利嗪。统计两组临床效果、不良反应情况,并对比两组治疗前后3个月眩晕累计发作次数、天数及治疗前后眩晕发作强度。结果两组临床总有效率相比,研究组93.10%(27/29)远高于对照组65.52%(19/29),差异有统计学意义(P<0.05);治疗后,与对照组相比,研究组眩晕累及发作次数、天数较少,眩晕发作强度较低,差异有统计学意义(P<0.05);研究组不良反应发生率10.35%(3/29)与对照组3.45%(1/29)相比,差异无统计学意义(P>0.05)。结论盐酸氟桂利嗪应用于VM预防性治疗中,效果更为显著,可明显减少患者眩晕累及发作次数、天数,降低眩晕发作强度,且安全性较高。Objective To investigate the effect of flunarizine hydrochloride in the prevention of vestibular migraine （VM） and its effect on vertigo intensity in patients. Methods Selected 58 patients with VM in Zhengzhou Central Affiliated Hospital of Zhengzhou University were divided into control group and study group according to different treatment methods, each group 29 cases. Both groups were given vertacaine mesylate tablets during the onset of vertigo, on this basis, the study group was given flunarizine hydrochloride. Clinical effects, adverse reactions were statistically analyzed between the two groups, and the dizziness cumulative number of attacks, the number of days at 3 mouths before and after treatment, vertigo intensity before and after treatment were compared between the two groups. Results The total effec- tive rate of the study group 95.5% （27/29） was higher than that of the control group （65.52%, 19/29）, the difference was statistically significant （ P 〈 0. 05 ） ; After treatment, compared with the control group, the dizziness cumulative number of attacks, the number of days in the study group were less, and vertigo intensity was lower, the difference was statistically significant （P 〈 0. 05 ） ; There was no significant difference in the incidence of adverse reactions between the study group 10. 35% （3/29） and the control group （3.45%, 1/29） （P 〉0. 05）. Conclusion Preventive treatment of VM using flunarizine hydrochloride gets a more obvious effect, which can significantly reduce the dizziness cumulative number of attacks, the number of days, reduce the vertigo intensity, and the safety is higher.

关 键 词：盐酸氟桂利嗪 VM 眩晕 

分 类 号：R747.2[医药卫生—神经病学与精神病学]