主动脉夹层发病机制的研究进展  

Research Progress in the Pathogenesis of Aortic Dissection

作　　者：郭义山[1] 丛超[1] 杨宁[1] 王东[1] 

机构地区：[1]滨州医学院附属医院心内科,山东滨州256600

出　　处：《医学综述》2017年第12期2339-2343,共5页Medical Recapitulate

基　　金：山东省高等学校科技计划项目(J14LL01)

摘　　要：主动脉夹层是一种严重危害人类健康的心血管急危重症,其发病迅速,临床症状不典型,极易误诊、误治。其发病因素众多,发病机制尚不明确,目前发病机制的研究主要集中在遗传因素、炎症机制、氧化应激以及外伤等方面。我国主动脉夹层的诊疗特点是临床表现多种多样,发病年龄趋于年轻,病死率较高,临床并发症多。该病的主要致死原因为主动脉夹层动脉瘤破裂至胸、腹腔或者心包腔,进行性纵隔、腹膜后出血,以及急性心力衰竭或者肾衰竭。该文就主动脉夹层领域内的现状、问题及最新进展进行综述,提高临床医师对该病的认识和重视,为主动脉夹层的诊治提供依据。Aortic dissection is a critical cardiovascular disease,which is seriously harmful to human health,featured with a rapid onset and atypical clinical symptoms,which may easily result in misdiagnosis and mistreatment. The pathogenic factors of this disease is numerous,and the pathogenesis is not clear. At present,the research of pathogenesis is mainly focused on genetic factors,inflammatory mechanisms,oxidative stress and trauma. The characteristics of diagnosis and treatment of aortic dissection in China are as follows： a variety of clinical manifestations and complications,age of onset tends to be young,high mortality. The main cause of death of the disease is the rupture of aortic dissection to the chest,abdominal cavity or pericardial cavity,progressive mediastinal and retroperitoneal hemorrhage,and acute heart failure or renal failure.Here is to make a review of the current situation,problems and latest progress in the field of aortic dissection,so as to improve the cognition of the clinicians on this disease,and provide references for the diagnosis and treatment.

关 键 词：主动脉夹层 发病机制 MARFAN综合征 睡眠呼吸暂停低通气综合征 

分 类 号：R576[医药卫生—消化系统]