海尔福对铝暴露大鼠血浆NOS,T-SOD及MDA的干预效应  

Intervention effects of Haierfu on plasma NOS,T-SOD,and MDA in rats exposed to aluminum

作　　者：李根亮[1] 李韬[1] 许苡侥 谢孟林 王红丽[1] 叶芳[1] 许文婷[1] 唐媛媛[1] 唐秀芬[1] 梁宇[1] 卢舒雨 胡红柳[1] 张树球[1] 

机构地区：[1]右江民族医学院,广西百色533000

出　　处：《右江民族医学院学报》2017年第3期183-185,189,共4页Journal of Youjiang Medical University for Nationalities

基　　金：广西自然科学基金(2014GXNSFAA118255)

摘　　要：目的探讨海尔福对铝致痴呆的可能干预效果及其可能干预机制。方法通过对大鼠饲喂氯化铝构建老年痴呆症(AD)大鼠模型,并采用中药提取液海尔福干预喂养铝暴露大鼠,分析比较各组大鼠(正常对照组、铝暴露组和海尔福干预组)在水迷宫中的行为特征及血浆中一氧化氮合酶(NOS)活性、总超氧化物歧化酶(T-SOD)活性及丙二醛(MDA)含量的变化。结果与正常对照组相比,铝暴露大鼠出现了AD特征,如在目的象限的活动时间缩短(P<0.01),血浆中NOS和T-SOD的活性分别升高(P<0.01)和下降(P<0.01),MDA的含量升高(P<0.01)。海尔福干预则能有效改善铝暴露大鼠的以上各项指标。结论铝暴露能引起大鼠的学习障碍,而海尔福则通过降低NOS的活性、提高T-SOD的活性和降低MDA的含量,防止大鼠学习能力障碍的产生,从而预防铝致老年痴呆症的发生。Objective To investigate the possible intervention effects mentia and its possible intervention mechanism. Methods The rats were of Haierfu on aluminum induced de- randomly divided into three groups： control group, aluminum-exposed group, and Haierfu intervention group. The rat models of Alzheimer＇s disease （AD） were established by feeding the rats with aluminum chloride. The rats exposed to aluminum were fed with Haierfu for analyzing the abnormal behavioral characteristics in the Morris water maze and the altera- tions of plasma nitric oxide synthase （NOS） activity, plasma total superoxide dismutase （T-SOD） activity and plasma malondialdehyde （MDA） content by comparison those indexes in rats of three groups mentioned above. Results Compared to the normal control group, there were obvious AD characteristics in rats exposed to a luminum, such as the activity time of the rats in the target quadrant shortened （ P 〈0.01）, the activity of plasma NOS increased （ P〈0.01）, the activity of plasma total SOD decreased （ P〈0.01）, and the content of plasma MDA increased （ P〈0.01）. Haierfu intervention can bore in aluminum-exposed rats. Conclusion The aluminum effectively improve the indicators mentioned a- exposure can cause learning disabilities in rats, but Haierfu can prevent the occurrence of learning disabilities and by increasing the activity of plasma total SOD, decreasing the activity of plasma NOS, and reducing the content of plasma MDA in rats, and aluminum- induced elderly AD was also prevented by the treatment with Haierfu.

关 键 词：海尔福口服液 铝暴露 大鼠 血浆 干预效应 

分 类 号：R745.7[医药卫生—神经病学与精神病学]