玉米微孔淀粉制备止血剂研究  

Research on the Hemostatic Preparation with Corn Microporous Starch

作　　者：边文海 刘成程[2] 李倩[2] 王超展[1] 边六交[2] BIAN Wenhai LIU Chengcheng LI Qian WANG Chaozhan BIAN Liujiao(College of Chemistry and Materials Science, Northwest University, Xi＇an 710069, China College of Life Sciences, Northwest University, Xi＇an 710069, China)

机构地区：[1]西北大学化学与材料科学学院,西安710069 [2]西北大学生命科学学院,西安710069

出　　处：《生物技术进展》2017年第4期320-326,J0002,J0003,共9页Current Biotechnology

基　　金：陕西省科技统筹创新工程计划项目(2016KTCQ02-18);陕西省科技研究发展(攻关)计划项目(2013K01-48-01)资助

摘　　要：为了制备玉米微孔淀粉止血剂,并对止血剂性能进行评价研究,采用酸酶序解法制备玉米微孔淀粉,测定其孔密度和吸水率,用动物创面出血模型检验其止血效果。研究结果显示,该方法所得微孔淀粉孔密度为3.4×10~4/mm^2,吸水率为156.98%,无病原微生物和内毒素;兔耳创面和兔肝脏创面完全止血时间分别在140 s和80 s之内,止血迅速、牢固,优于云南白药。研究结果表明,该微孔淀粉组织相容性良好,符合生物材料安全性的要求,可望开发为新型止血材料。To prepare and evaluate the hemostatic that made of corn microporous starch, a sequential hydrochloric acid and composite enzyme hydrolysis method was utilized for preparation of corn microporous starch. The density and water-absorbing ratio of the microporous starch were determined. The hemostatic effect was evaluated by animal wound hemorrhage model. Results showed that, the density and water-absorbing ratio of the microporous starch were determined to be 3.4×10^4/mm^2 and 156.98%, respectively. The microorganism and endotoxin had been picked out. The hemostatic time of the mieroporous starch to the rabbit ear and liver trauma were within 140 s and 80 s, and the hemostasis effect was superior to Yunrtan Baiyao. The microporous starch had good biocompatihility and met the safety criterion of biomateriai. It has potential to be a promising biomaterial for hemostasis.

关 键 词：玉米淀粉 微孔淀粉 止血剂 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]