Bilirubin Lowering Potential of Aqueous Carica Papaya Extract in Induced Jaundice in Rats  

作　　者：M. I. Ayeni M. A. Akanmu O. O. Bolaji S. A. Osasan G. Olayiwola1, M. O. Afolabi1, A. M. Morohunfola 

机构地区：[1]Department of Clinical Pharmacy and Pharm Admin, ObafemiAwolowo University, Ile-Ife 220282, Nigeria [2]Department of Pharmacology, ObafemiAwolowo University, Ile-Ife 220282, Nigeria [3]Department of Pharmaceutical Chemistry, ObafemiAwolowo University, Ile-Ife 220282, Nigeria [4]Department of Pathology, Ondo State Hospitals Management Board, Akure 340,Nigeria [5]Tots & Tykes Pediatrics, 3750 S University Dr Ste 200 Fort Worth, Arlington TX 76006, USA

出　　处：《Journal of Pharmacy and Pharmacology》2017年第7期457-466,共10页药剂与药理学（英文版）

摘　　要：Background： The mature unripe fruit of aqueous Carica papaya （ACP） is used in Nigerian traditional medicine for the treatment of jaundice. Work done on aqueous extract of the unripe C. papaya in an acute oral toxicity study in rats showed the LD50 to be 2,520 mg/kg in rats. Current study evaluated the bilirubin-lowering potential of ACP extract in phenylhydrazine （40 mg/kg） induced jaundice in adult rats. Method： Jaundice was assessed by measuring the levels of TB （total bilirubin） and DB （direct bilirubin） in phenylhydrazine-treated animals with or without drug treatment, with CUR （curative）, PRO （prophylactic study）, and in animals with RLC （reduced liver capacity）. Results： Result demonstrated that TB level of 24.0 μmols/L, 22.0 μmols/L and 45.0 μmols/L in the jaundiced group of the CUR, PRO and RLC respectively was significantly lowered （p 〈 0.05） to 10.0, 13.0, and 17.0 respectively by 400 mg/kg of the extract. Total bilirubin level of 24.0 btmols/L, 22.0 lamols/L and 45.0 μmols/L in the jaundiced group of the CUR, PRO and RLC respectively was significantly lowered （p 〈 0.05） to 7.0, 10.0, and 17.0 respectively by 800 mg/kg extract. Conclusion： The study concluded that ACP fruit extract has ability to lower elevated bilirubin level and confer hepatoprotective effect as seen from the liver function test indices thus justifying its ethnomedicinal use.

关 键 词：Carica papaya unripe fruit HEPATOPROTECTIVE BILIRUBIN PHENYLHYDRAZINE JAUNDICE rats. 

分 类 号：TS202.3[轻工技术与工程—食品科学] Q421[轻工技术与工程—食品科学与工程]