EGCG防治糖尿病作用及机制研究进展  

Research progress on the effect and mechanism of EGCG in the prevention and treatment of diabetes mellitus

作　　者：张灵枝[1] 邓旭铭 潘顺顺[1,2] 赖幸菲[2] 孙世利[2] 陈文品[1] 

机构地区：[1]华南农业大学园艺学院,广东广州510642 [2]广东省农业科学院茶叶研究所/广东省茶树资源创新利用重点实验室,广东广州510640

出　　处：《华南农业大学学报》2017年第5期50-55,共6页Journal of South China Agricultural University

基　　金：广东省科技计划项目(2016B090918118;2016A020212015;2014A070713012;2015B090906027)

摘　　要：表没食子儿茶素没食子酸酯(Epigallocatechin gallate,EGCG)是绿茶中的主要活性成分,具有抗癌、抑制肥胖、缓解代谢综合征等功效。本文总结EGCG预防和缓解糖尿病的相关研究,从降血糖功效、胰岛素抵抗、胰岛素分泌、糖尿病常见并发症等方面综合分析和阐述EGCG的作用机制,以期为绿茶缓解代谢综合征研究提供理论支持。Epigallocatechin gallate(EGCG) is the main active compound in green tea. It has the functions of anticancer, anti-obesity, alleviating metabolic syndrome and so on. This paper reviews the researches about EGCG on prevention and treatment of diabetes mellitus, and summarizes the functions of EGCG in hypoglycemic activity,insulin resistance, insulin secretion and common complications of diabetes. This paper aims to provide theoretical support for studying the alleviation of metabolic syndrome by green tea.

关 键 词：EGCG 糖尿病 胰岛素抵抗 胰岛素分泌 绿茶 信号通路 

分 类 号：R587.1[医药卫生—内分泌]