液相色谱串联质谱分析酒类产品中他达那非等11种非法添加药物方法研究  

Determination of Eleven Kinds of Illegal Additive Drug Including Tadalafil by Liquid Chromatography-tandem Mass Spectrometry

作　　者：孙长华[1] 刘晓玲[1] 张欣[2] SUN Changhua LIU Xiaoling ZHANG Xin(Academy of Quality Inspection and Research in Heilongjiang Province,Harbin 150028,Heilongjiang, China Heilongjiang Academy of light industry, Harbin 150010, Heilongjiang,China)

机构地区：[1]黑龙江省质量监督检测研究院,黑龙江哈尔滨150050 [2]黑龙江省轻工科学研究院,黑龙江哈尔滨150010

出　　处：《酿酒》2017年第4期108-111,共4页Liquor Making

摘　　要：建立了配制酒产品中伐地那非、那红地那非、红地那非、羟基豪莫西地那非、西地那非、豪莫西地那非、氨基他达那非、他达那非、硫代艾地那非、伪伐地那非、那莫西地那非等11种药物残留量的高效液相色谱法测定和液相质谱联用法定性确认方法。对色谱柱选择、流动相组成、梯度洗脱条件进行实验,最终采用C18分离柱(150×2.1 mm×5 μm)乙腈和0.1%甲酸作为流动相,确定质谱分析方法。并检测了枸杞酒、苦瓜酒等十余种配制酒中的他达那非等11种非法添加物,效果良好。The qualitative determination of eleven kinds of illegal drug residues of vardenafil, noracetildenafil, acetildenafil,hydroxyhomosildenafil, sildenafil, homosildenafil, amino-tadalafil, tadalafil, thioaildenafil, pseudo-vardenafil, norneosildenafil by liquid chromatograph-tandem mass spectrometry was established. The experiments on column selection, composition of mobile phase, gradient elution conditions were carried out. Finally, the mass spectrometry method was determined by using C18 column（150×2.1 mm×5 μm）, and acetonitrile with 0.1% formic acid as mobile phase. In addition, detection of the above eleven kinds of illegal additive including tadalafils in more than ten blending liquors such as wolfberry liquor, bitter gourd liquor were performed and good results were obtained.

关 键 词：他达那非 配制酒 液相色谱串联质谱 

分 类 号：TS262.7[轻工技术与工程—发酵工程] TS207.3[轻工技术与工程—食品科学与工程]