浙江沿海与内陆地区食管癌家族史的分布比较  

Comparison of family history distribution of esophageal carcinoma in Zhejiang coastal area and inland area

作　　者：郑伟慧[1,2] 徐晓玲[2] 刘玮[2] 凌志强[2] 毛伟敏[2] ZHENG Wei-Hui XU Xiao-Ling LIU Wei LING Zhi- Qiang MAO Wei-Min(The First Affiliated Clinical College of Sooehow University, Soochow 215000, China Key Laboratory of Thoracic Tumor in Zhe- jiang Cancer Hospital, Hangzhou 310022, China)

机构地区：[1]苏州大学附属第一临床医学院,江苏苏州215000 [2]浙江省肿瘤医院胸部肿瘤中心重点实验室,浙江杭州310022

出　　处：《转化医学电子杂志》2017年第6期49-53,共5页E-Journal of Translational Medicine

基　　金：国家自然科学基金(31470111)

摘　　要：目的:分析浙江省肿瘤医院食管癌家族史的分布情况,为该病的预防与控制提供线索,为进一步的转化及基础研究提供素材.方法:选取2005~2015年就诊于浙江省肿瘤医院的4185例食管癌患者的病历资料进行分项总结分析.同时将来自台州、杭州、衢州、金华、湖州5个地区的患者归为一组,另一组来自温州、舟山、宁波等相对沿海的6个地区.比较两组患者在一般情况及肿瘤家族史方面的差异.结果:4185例患者就诊年龄59.37±9.02岁,男3691例,女494例,男女性别比为7.47∶1,来自台州等地区的肿瘤家族史阳性率12.93%,温州沿海地区7.36%.两组比较,差异具有统计学意义(P<0.05,χ~2=32.004).结论:浙江省肿瘤医院食管癌患者的基本情况符合食管癌一般的流行病学特征.内陆地区食管癌家族史阳性率高于沿海地区.加强内陆地区食管癌的筛查有利于更好地预防和控制该疾病.AIM： To analyze the distribution of family history of esophageal carcinoma in Zhejiang Cancer Hospital for providing clues for the prevention and control of the disease, and providing materials for further translational and basic research. METHODS： The medical records of 4185 eases with esophageal carcinoma in Zhejiang Cancer Hospital from 2005 to 2015 were analyzed. We divided those cases into two groups. The inland area included Taizhou, Hangzhou, Quzhou, Jinhua and Huzhou. The coastal ar- eas included Wenzhou, Zhoushan, Ningbo and other 6 regions. The general situation and differences in carcinoma family histories of the two groups were compared. RESULTS： The age was 59.37 ~9.02 in 4185 patients. There were 3691 males and 494 females. The sex ratio was 7.47 ： 1. The positive rate of carcinoma family was 12.93% in inland area such as Taizhou, and the positive rate of carcinoma family was 7.36% in coastal area such as Wenzhou. There was a statistically significant difference between two groups （P〈0.05, X2 = 32.004）. CONCLUSION： The situations of pa- tients with esophageal carcinoma in Zhejiang Cancer Hospital were consistent with general epidemiology of esophageal cancer. The rate of positive carcinoma family in inland area was higher than that of coastal area. Strengthening the screening of esophageal carcinoma in the inland area is beneficial to prevent and control the disease.

关 键 词：食管癌 家族成员 地理 流行病学 

分 类 号：R735.1[医药卫生—肿瘤]