小檗碱药理作用及其临床应用研究进展  

Progress in pharmacological effects and clinical applications of berberine

作　　者：邢宇[1,2] 刘鑫[1] 林园[1] 张勇[1,3,4] 

机构地区：[1]哈尔滨医科大学药学院药理学教研室黑龙江省生物医药重点实验室-省部共建国家重点实验室培育基地心血管药物研究教育部重点实验室,黑龙江哈尔滨150081 [2]哈尔滨医科大学基础医学院,黑龙江哈尔滨150081 [3]哈尔滨医科大学 [4]中俄医学研究中心代谢疾病研究所黑龙江省医学科学院,黑龙江哈尔滨150086

出　　处：《中国药理学与毒理学杂志》2017年第6期491-502,共12页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81570399)~~

摘　　要：小檗碱是从传统中药黄连和黄柏中提取出的一种异喹啉类生物碱,在我国拥有悠久的药用历史。小檗碱具有多种药理作用,包括抗病原微生物、抗炎、抗肿瘤、心脏保护、降血糖、调节脂质代谢以及免疫抑制等。多年以来,小檗碱用于肠道感染性疾病的治疗取得显著疗效。近年来,随着研究的不断进展,其临床应用潜力不断被开发,对心血管系统疾病、代谢综合征及其并发症、肿瘤、腹腔黏连和沙眼衣原体感染等均具有较好的效果。本文针对小檗碱多方面的药理作用、分子机制及临床应用现状进行梳理总结,为小檗碱的临床应用和推广提供参考。Berberine is an isoquinoline alkaloid isolated from Rhizoma Coptidis and Cortex Phel odendri,which has a long medical history in China. Recent studies have indicated that berberine has multiple pharmacological activities including anti-inflammatory, anti-microorganisms, anti-cancer, cardiac protection, glucose lowering, regulating lipid metabolism and immune suppression. Berberine has been used for the treatment of intestinal infectious diseases for many years. With the continuous progress of the research, it is reported that berberine has many new clinical applications, including treatment of the cardiovascular disease, metabolic syndrome and its complications, cancers, abdominal adhesions and chlamydia trachomatis infection. This review is intended to introduce the role of berberine in various aspects of pharmacological effects, molecular mechanisms and clinical applications.

关 键 词：小檗碱 抗炎 抗病原微生物 抗肿瘤 心脏保护 降血糖 降血脂 免疫抑制 

分 类 号：R285[医药卫生—中药学]