胃癌组织氨基酸代谢的研究  

Recent Studies on Amino Acid Metabolism in Gastric Carcinoma

作　　者：赵春临[1] 董志远[1] 余洋[1] 张红雨[1] 李鹏辉[1] 王水生[1] 丁朝辉[1] 徐化楠 Zhao Chunlin Dong Zhiyuan Yu Yang Zhang Hongyu Li Penghui Wang Shuisheng Ding Chaohui Xu Huanan(The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Chin)

机构地区：[1]郑州大学第一附属医院胃肠外科,河南郑州450052

出　　处：《河南医学研究》2017年第15期2696-2699,共4页Henan Medical Research

摘　　要：目的观察胃癌组织、癌旁正常组织氨基酸谱的变化规律。方法使用超高效液相色谱串联质谱的方法检测40例胃癌患者癌组织、癌旁正常组织19种氨基酸的含量。结果Ⅰ、Ⅱ期胃癌组织中氨基酸含量与癌旁正常组织相比,差异无统计学意义,Ⅲ、Ⅳ期胃癌组织中氨基酸与癌旁正常组织相比,苏氨酸、酪氨酸、丝氨酸、甘氨酸、缬氨酸、脯氨酸、蛋氨酸和谷氨酰胺的含量增加,差异均有统计学意义(P<0.05)。结论Ⅲ、Ⅳ期胃癌组织中多种氨基酸含量升高,表明胃癌组织存在明显的氨基酸代谢异常,这种代谢异常可为氨基酸失衡疗法提供临床依据。Objective To investigate the metabolism of amino acids in gastric carcinoma tissues and adjacent normal tissues. Methods Nineteen kinds of amino acids in gastric carcinoma tissues and adjacent tissues were detected by ultrahigh performance liquid chromatography（UPLC） tandem masss pectrometry method. Results The contents of amino acids were not significantly changed in gastric carcinoma with I and II stage, Compared with adjacent normal tissues, contents of Thr, Tyr, Ser, Gly, Val, Pro, Met and Gin increased significantly in gastric carcinoma tissues with mand IVstage. Conclusions The amino acid in gas- tric carcinoma tissues with II[ and IVstage were significantly changed, which showed that there were obvious metabolism abnormal- ities of amino acid in gastric carcinoma, providing clinical evidence for amino acid imbalance therapy.

关 键 词：胃癌 氨基酸 超高效液相色谱串联质谱 氨基酸失衡疗法 

分 类 号：R735.2[医药卫生—肿瘤]