Machado Joseph病的非运动障碍症状  

Non-dyskinesia Symptoms of Machado Joseph Disease

作　　者：刘国懿[1] 陈涛[1] 

机构地区：[1]昆明医科大学第一附属医院神经内科,云南昆明650032

出　　处：《系统医学》2017年第6期158-161,共4页Systems Medicine

摘　　要：脊髓小脑性共济失调3型(Machado-Joseph disease,MJD)是遗传性脊髓小脑性攻击失调最常见的亚型,临床诊断多以患者的临床症状与基因检测为依据,目前尚无特效的治疗药物。临床治疗多以对症治疗以及延缓患者病程进展为原则。MJD患者的运动障碍症状较为明显,但随着临床研究的不断深入,MJD患者的非运动障碍症状越来越受到人们的重视。该文对MJD患者的睡眠障碍、认知情感障碍、精神症状、嗅觉障碍、疼痛、疲劳、营养方面、眼科表现及自主神经功能障碍等非运动障碍症状进行阐述,以提高对MJD的诊断率,利于患者及时治疗。Machado-Joseph disease is the most common subtype of hereditary spinocerebellar disorder, currently, there is no special treatment drugs and the clinical symptoms and gene test are usually used as the basis in clinical diagnosis, and in the clinical treatment, the symptomatic treatment and prolonging the progress of labor course of patients are used as the principle, and the motor disorder symptoms of MJD patients is obvious, but with the continuous deepening of clinical research, people pay more and more attention to the non-dyskinesia symptoms of Machado Joseph disease, and the paper elaborates the sleep disorder, cognitive and emotional disorder, mental symptom, dysosmia, pain, fatigue, nutrition, manifestations in the department of ophthalmology and dysautonomia in order to improve the diagnosis rate of MJD, which is conducive to the timely treatment of patients.

关 键 词：MACHADO-JOSEPH病 非运动障碍 睡眠障碍 疲劳 疼痛 

分 类 号：R741.041[医药卫生—神经病学与精神病学]