客家娘酒对衰老小鼠免疫功能及抗氧化的影响  

Effects of Hakka rice wine on antioxidant activity and immunity of the aging mice

作　　者：罗铝铿[1] 邹浩元[1] 曾海敬[2] 董志会 

机构地区：[1]嘉应学院医学院,梅州514015 [2]梅州市人民医院,梅州514015

出　　处：《食品科技》2017年第8期105-108,共4页Food Science and Technology

基　　金：广东省创新强校工程课题(20141275);全国大学生创新创业训练计划项目(201510582020);梅州市产业研究与技术开发资金项目(201411);广东省医学科学基金项目(B2016062)

摘　　要：目的:研究客家娘酒对D-半乳糖所致亚急性衰老小鼠抗氧化能力及免疫功能的影响。方法:采用腹腔注射D-半乳糖建立亚急性衰老小鼠模型,分别灌胃蒸馏水和不同浓度的黄酒,每天1次,连续灌胃45 d,测定小鼠肝、脑中的超氧化物歧化酶(Superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)活性,丙二醛(Malondialdehyde,MDA)含量,血清白细胞介素6(Interleukin-6,IL-6)、肿瘤坏死因子α(Tumor necrosis factorα,TNF-α)以及胸腺、脾脏指数。结果:客家娘酒能显著提高衰老小鼠肝脏、脑SOD、GSH-Px活性,降低肝脏、脑中的MDA含量,能显著抑制衰老小鼠胸腺和脾脏指数的下降,显著降低血清IL-6、TNF-α水平。结论:客家娘酒具有增强衰老小鼠抗氧化能力以及调节免疫功能的作用。Objective： The aim of this study was to evaluate the effects of Hakka rice wine （HRW） on antioxidant activity and immune function of the aging mouse induced by D-galactose. Method： The model of subacute aging mice were established by intraperitoneal injection of D-gatactose and given distilled water, HRW once a day by intragastric administration for 45 days. Then, mice were sacrificed, and the brain and liver SOD, GSH-Px, MDA, thymus index, spleen index and the serum IL-6, TNF-α were measured. Result： The HRW could obviously increase activity of liver and brain SOD, GSH-Px, the thymus index, the spleen index, decrease the content of liver and brain MDA, the level of serum IL-6, TNF-α. Conclusion： The HRW can improve the antioxidant activity and enhance the immunity of the aging mice.

关 键 词：客家娘酒 抗氧化 免疫功能 衰老 

分 类 号：TS262.4[轻工技术与工程—发酵工程]