二代测序在胶质瘤研究与个体化治疗中的应用  

Application of next-generation sequencing in research and personalized treatment of glioma

作　　者：王洪祥[1] 秦荣[2] 符达 陈菊祥[1] 

机构地区：[1]第二军医大学长征医院神经外科上海市神经外科研究所全军神经外科研究所,上海200003 [2]解放军184医院神经外科,鹰潭335000 [3]中国科学院上海生物科学研究所健康科学研究所,上海200032

出　　处：《第二军医大学学报》2017年第8期1046-1052,共7页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81272781);Supported by National Natural Science Foundation of China(81272781);上海市卫生系统优秀学科带头人新百人计划(XBR02011030);New One Hundred Talents Program of Leading Scientists of Shanghai Health System(XBR2011030);上海市曙光学者计划(11SG37).Shuguang Project of Shanghai(11SG37)

摘　　要：脑胶质瘤是一类高度致死性恶性肿瘤,目前有关其在基因组学的研究及临床治疗存在诸多挑战。二代测序技术具有高通量优势,能通过对肿瘤全基因组、外显子组、转录组及表观遗传组全面分析加深对肿瘤基因组学的认识,并已成功应用于部分肿瘤的临床研究中,为肿瘤个体化靶向治疗提供合适可行的指导。当前,运用二代测序研究胶质瘤已成为热点,将全面阐明胶质瘤致病机制,并为制定个体化治疗方案提供策略,使患者获益。Glioma is a highly lethal malignancy and multiple challenges remain for it in the genomic study and clinical treatment.Next-generation sequencing（NGS）holds many advantages,and NGS can comprehensively analyze the whole genome,exome,transcriptome and epigenome to deepen the understanding of tumor genomics;and now,it has been successfully applied in the clinical study of some tumors,especially in personalized treatment for these tumors.At present,NGS has also been a hot in glioma research to clarify the pathogenesis of glioma,so as to draw up apersonalized treatment method to benefit the patients.

关 键 词：脑肿瘤 胶质瘤 DNA序列分析 个体化治疗 

分 类 号：R739.41[医药卫生—肿瘤]