国家自然科学基金(81272781);Supported by National Natural Science Foundation of China(81272781);上海市卫生系统优秀学科带头人新百人计划(XBR02011030);New One Hundred Talents Program of Leading Scientists of Shanghai Health System(XBR2011030);上海市曙光学者计划(11SG37).Shuguang Project of Shanghai(11SG37)