Peroxiredoxins在肿瘤中的研究进展  

Study development of Peroxiredoxins in tumors

作　　者：曾伟[1,2] 肖涛[1] 蔡安烈 

机构地区：[1]中南大学湘雅二医院骨科,湖南长沙410011 [2]中南大学湘雅医学院附属株洲医院暨株洲市中心医院骨科,湖南株洲412000

出　　处：《中国医药导报》2017年第25期38-41,57,共5页China Medical Herald

基　　金：湖南省自然科学基金项目(2017JJ4068);湖南省医药卫生科研计划项目(B2016172)

摘　　要：Peroxiredoxins(Prdx)是细胞内存在一类抗氧化酶,它们能催化氧化还原反应而维持细胞内过氧化氢水平的平衡,并作为氧化还原信号通路中的一个重要调节因子,这对于细胞信号转导和代谢十分重要。Prdx家族在肿瘤中发挥着不同的作用。由于肿瘤基因组学的改变,它们的表达发生变化,随之而来是细胞内氧化还原信号通路的改变。这些变化对肿瘤的生物学行为产生重要影响,也为肿瘤的治疗提供了契机。因此,我们对目前Prdx在肿瘤中的研究进展进行简要概括,从而为肿瘤的治疗提供新的方向。Peroxiredoxins （Prdx） is one kind of antioxidant enzymes in cells which can catalysis oxidation-reduction reactions to balance the level of hydrogen peroxide. They can also act as an important regulator in oxidation-reduction signal pathway, which is important for signal transduction and metabolism in cells. Many studies have showed that Prdx family plays different roles in tumors. Because of the change oftumor gene groups, their expressions changed, with the change of oxidation-reduction signal pathway. These changes lead to the influence of biological actions of tumors, of-fering new ideas of treatment of tumors. Therefore, we make a short conclusion of study about Prdx in tumors, in order to find a new way to treat tumors.

关 键 词：PEROXIREDOXINS 肿瘤 活性氧簇 氧化还原 治疗 

分 类 号：R73[医药卫生—肿瘤]