丁酸氯维地平中间体丁酸氯甲酯的合成  

Synthesis of Chloromethyl Butyrate as Clevidipine Butyrate Intermediate

作　　者：李公春[1] 谢智宇 侯旭锋[1] 田源[1] 吴长增[1] 

机构地区：[1]许昌学院化学化工学院化学生物传感与检测重点实验室,河南许昌461000

出　　处：《山东化工》2017年第16期7-8,共2页Shandong Chemical Industry

基　　金：许昌市科技发展计划项目(编号:1502083);河南省高等学校重点科研项目(编号:16B350003)

摘　　要：以丁酸为原料,三氯化磷为氯化试剂,合成了丁酰氯,产率为81.5%。以氯化锌为催化剂,丁酰氯与多聚甲醛在60℃下进行反应,合成了丁酸氯维地平中间体丁酸氯甲酯,产率为66.2%。Butyryl chloride was synthesized from butyric acid using phosphorus trichloride as chlorination reagent. The yield of reaction was 81. 5%. Chloromethyl butyrate as clevidipine butyrate intermediate was synthesized from butyryl chloride and paraformaldehyde using zinc chloride as catalyst at 60℃. The yield of reaction was 66. 2%.

关 键 词：丁酸氯维地平 丁酸氯甲酯 合成 

分 类 号：O621.3[理学—有机化学]