脑性瘫痪婴儿的白质脑网络研究  

Research on brain white matter network in cerebral palsy infant

作　　者：李均[1] 杨澄[1] 王远军[1] 聂生东[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《生物医学工程学杂志》2017年第5期688-694,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金(61201067);微创励志创新基金(YS30809134)

摘　　要：本文使用弥散张量成像及白质纤维束追踪技术构建和分析了15名脑性瘫痪患儿和30名正常婴儿大脑的白质脑网络,发现脑性瘫痪患儿和正常婴儿的白质脑网络都具有"小世界"属性,但患儿的最短路径长度明显变长,而标准聚类系数、全局效率和局部效率明显下降。此外,我们还发现左脑楔叶、左右脑楔前叶以及左脑扣带回后部是婴儿白质脑网络的核心节点,患儿白质脑网络的部分节点存在异常,且异常节点多集中于颞叶、枕叶和顶叶。本文结果表明脑性瘫痪婴儿的白质脑网络已经出现紊乱的现象,这为我们进一步研究脑性瘫痪儿童的发病机制提供了帮助。Present study used diffusion tensor image and tractography to construct brain white matter networks of 15 cerebral palsy infants and 30 healthy infants that matched for age and gender. After white matter network analysis, we found that both cerebral palsy and healthy infants had a small-world topology in white matter network, but cerebral palsy infants exhibited abnormal topological organization： increased shortest path length but decreased normalize clustering coefficient, global efficiency and local efficiency. Furthermore, we also found that white matter network hub regions were located in the left cuneus, precuneus, and left posterior cingulate gyrus. However, some abnormal nodes existed in the frontal, temporal, occipital and parietal lobes of cerebral palsy infants. These results indicated that the white matter networks for cerebral palsy infants were disrupted, which was consistent with previous studies about the abnormal brain white matter areas. This work could help us further study the pathogenesis of cerebral palsy infants.

关 键 词：脑性瘫痪 弥散张量成像 白质网络 图论 

分 类 号：O157.5[理学—数学] R742.3[理学—基础数学]