机器人与腹腔镜直肠癌低位前切除术临床疗效比较的Meta分析  

Comparison of clinical efficacy between robotic and laparoscopic low anterior resection for rectal cancer:a Meta analysis

作　　者：刘俊业[1] 傅平[1] 洪华章[1] 袁喜红[1] 李坚[1] 林良庆[1] 周凯[1] 

机构地区：[1]江西省人民医院普外科,南昌330006

出　　处：《重庆医学》2017年第29期4088-4092,共5页Chongqing medicine

基　　金：国家自然科学基金资助项目(81260368)

摘　　要：目的比较机器人直肠癌低位前切除术(R-LAR)与腹腔镜直肠癌低位前切除术(L-LAR)的临床疗效。方法计算机检索PubMed、OVID、Springer数据库、万方数据库(Wanfang)、中文科技期刊数据库(VIP),收集比较R-LAR与L-LAR临床疗效的病例对照研究,检索时间从建库至2016年6月。由两名研究者按照纳入排除标准选取研究,提取资料并评价后采用RevMan5.3软件进行分析。结果最终纳入7篇文献,共1 126例患者,其中R-LAR组592例,L-LAR组534例。Meta分析结果显示:R-LAR组手术时间较L-LAR组长(MD=33.84,95%CI:4.25~63.43,P=0.03),中转开腹率较L-LAR组低(OR=0.10,95%CI:0.03~0.36,P=0.000 5),淋巴结清扫数目较L-LAR组多(MD=1.24,95%CI:0.31~2.17,P=0.009);而两组总住院时间、术中出血量、远切缘距肿瘤距离及术后吻合口漏发生率比较,差异均无统计学意义(P>0.05)。结论在直肠癌低位前切除术中,机器人手术时间相对延长,但总住院时间、术中出血量、远切缘距肿瘤距离及术后吻合口漏发生率与传统腹腔镜手术相当,且中转开腹率更低、淋巴结清扫更彻底。Objective To compare the clinical efficacy of robotic low anterior resection （R-LAR） and laparoscopic low anterior resection （L-LAR） for rectal cancer. Methods The case-control studies for comparing the clinical efficacy of R-LAR and L- LAR for rectal cancer were retrieved from databases, including PubMed, OVID, Springer. Wanfang and VIP, till June 2016. The studies were selected in accordance with inclusion and exclusion critera,and the data were extracted and evaluated by two researchers. The RevManS. 3 software was used for Meta-analysis. Results A total of 7 studies including 1 126 patients with rectal cancer were included,592 cases in the R-LAR group and 534 cases in the L-LAR group. Compared with the L-LAR group.in the R-LAR group the operation time was longer （MD=33.84,95% CI：4.25-63.43,P=0. 03）.the conversion rate was lower （OR=0. 10, 95%CI：0.03 0.36,P=0. 000 5） ,and more lymph nodes were dissected （MD=1. 24,95%CI：0.31-2.17 ,P=0. 009）. No statistically significant difference was found in length of hospital stay,intraoperative blood loss, distance from distal margin to tumor and incidence rate of postoperative anastomotic leakage between the two groups （P〉 0.05）. Conclusion Compared with L-LAR, R- LAR is characterized by longer operation time,lower conversion rate and more thoroughly removing lymph nodes. And the length of hospital stay,intraoperative blood loss, distance from distal margin to tumor and incidence rate of postoperative anastomotic leakage of R-LAR are similar to those of L-LAR.

关 键 词：直肠肿瘤 机器人 腹腔镜 低位前切除 META分析 

分 类 号：R735.37[医药卫生—肿瘤]