非小细胞肺癌中PHF20与凋亡相关蛋白Bax的表达及相关性  

Expression and Correlation of PHF20 and Apoptosis-associated Protein Bax in Non-small Cell Lung Cancer

作　　者：姜西子 金艾琳 马琳 唐娜[1,2] 张清富[1,2] 孙丽梅[1,2] 邱雪杉[1,2] 

机构地区：[1]中国医科大学附属第一医院病理科,沈阳110001 [2]中国医科大学基础医学院病理教研室,沈阳110122

出　　处：《中国医科大学学报》2017年第10期887-890,902,共5页Journal of China Medical University

基　　金：基金项目:辽宁省教育厅高等学校创新团队(LT2015029)

摘　　要：目的探讨化疗前非小细胞肺癌中PHF20与Bax的表达差异及其相关性。方法采用免疫组化方法检测PHF20与Bax在非小细胞肺癌中的表达情况,分析PHF20的临床意义以及PHF20与Bax可能存在的相关性。结果非小细胞肺癌中PHF20蛋白在细胞质中表达。PHF20在鳞癌中高表达,在腺癌中低表达,并与细胞分化程度、TNM分期和淋巴结转移密切相关。肺鳞癌中PHF20和Bax的表达呈正相关。结论非小细胞肺癌中PHF20的表达变化与肿瘤进展密切相关,而且与Bax表达存在相关性,其具体机制的研究将很可能为非小细胞肺癌的治疗提供新的靶点。Objective To investigate the differences in the expression of PHF20 and Bax and their correlations in non-small cell lung cancer before chemotherapy. Methods An immunohistochemical method was used to detect the expression of PHF20 and Bax in non- small cell lung cancer, and to analyze the clinical significance of PHF20 and the possible correlation between PHF20 and Bax proteins. Results PHF20 protein is expressed in the cytoplasm of non-small cell lung cancer cells. Moreover,it is highly expressed in squamous cell carcinoma, less expressed in adenoearcinoma, and closely related with cell differentiation, TNM staging, and lymph node metastasis. The expression of PHF20 and Bax was positively correlated with squamous cell lung carcinoma. Conclusion The expression of PHF20 in non-small cell lung cancer is closely associated with tumor progression and the expression of Bax. PHF20 may be a new target for the treatment of non-small cell lung cancer.

关 键 词：非小细胞肺癌 PHF20 BAX 

分 类 号：R734.2[医药卫生—肿瘤]