EGFR、SOX2在结直肠癌中表达特征及临床价值  

Expression of EGFR and SOX2 and their clinical significance in colorectal carcinoma

作　　者：王艳霞 王玉艳[2] Wang Yanxia Wang Yuyan(Department of Laboratory, Anorectal Disease Hospital, Shengbei Community, Shengli Petroleum Administration Bureau, Dongying, Shandong, 257077,China Department of Laboratory, Central Hospital of Shengli Oil Field, Dongying, Shandong, 257000, China)

机构地区：[1]胜利石油管理局胜北社区肛肠病防治院检验科,山东东营257077 [2]胜利油田中心医院检验科,山东东营257000

出　　处：《结直肠肛门外科》2017年第4期451-454,共4页Journal of Colorectal & Anal Surgery

摘　　要：目的研究表皮生长因子受体(Epidermal growth factor receptor,EGFR)、性别决定区Y框蛋白2(sex determining region Ybox2,SOX2)在结直肠癌中表达特征及临床价值。方法采用免疫组化法测定本院55例结直肠癌患者肿瘤组织、癌旁组织中EGFR、SOX2表达情况,以染色强度、细胞数评估EGFR、SOX2阴、阳性,观察结直肠癌EGFR、SOX2阳性患者的临床资料特征以评价上述指标与病理特征的关系,采用Spearman等级相关分析EGFR、SOX2在结直肠癌中表达的相关性。结果肿瘤组织EGFR(+)、SOX2(+)率与癌旁组织各项指标阳性率比较均显著较高(P<0.05);不同Dukes分期、分化程度及淋巴结转移EGFR、SOX2阳性表达存在显著差异(P<0.05),EGFR、SOX2与性别、年龄、肿瘤部位无关(P>0.05)。Spearman等级相关分析,结直肠癌组织内EGFR与SOX2表达正相关(r=0.674,P=0.000)。结论 EGFR、SOX2在结直肠癌肿瘤组织、癌旁正常组织内表达存在明显差异,其表达水平与结直肠癌Dukes分期、分化程度及淋巴结转移有关。Objective To study the expression of epidermal growth factor receptor（EGFR） and sex determining region Y box protein2（SOX2） and their clinical significance in colorectal carcinoma. Methods Immuno histochemical method was used to study the expression of EGFR and SOX2 in tumor tissues and adjacent tissues of 55 patients with colorectal carcinoma in our hospital. Positive and negative expression of EGFR, SOX2 were evaluated by staining intensity and the number of cells, Spearman rank correlation analysis was conducted to observe the the relationship between clinical characteristics of EGFR and SOX2 in colorectal carcinoma, and their pathological features. Results The positive rates of EGFR（＋）and SOX2（＋）in tumor tissues were significantly higher than the adjacent tissues（P 〈 0.05）. The positive expression of EGFR and SOX2 were significantly different in different stages of Dukes, differentiation and lymph node metastasis（P 〈 0.05）. While there were no significant difference in EGFR and SOX2 in different sex, age and tumor location（P 〈 0.05）. Spearman rank correlation analysis showed that the expression of EGFR was positively correlated with the expression of SOX2 in colorectal carcinoma tissues（r = 0.674, P = 0.000）. Conclusion The expressions of EGFR and SOX2 in colorectal carcinoma tissues and adjacent normal tissues were significantly different. The expression level was associated with the stage of Dukes,the degree of differentiation and lymph node metastasis of CRC.

关 键 词：结直肠癌 EGFR SOX2 

分 类 号：R735.34[医药卫生—肿瘤]