1036例高龄孕妇羊水细胞染色体核型分析  

Analysis of amniotic fluid karyotyping in 1036 pregnant women at advanced age

作　　者：陈巧媛[1] 王昕[1] 王威[1] 李维[1] 董媛[1] 王一鹏[1] 王树玉[1] CHEN Qiao-yuan WANG Xin WANG Wei LI Wei DONG Yuan WANG Yi-peng WANG Shu-yu(Prenatal Diagnosis Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026 China)

机构地区：[1]首都医科大学附属北京妇产医院产前诊断中心,北京100026

出　　处：《中国优生与遗传杂志》2017年第10期40-41,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的对高龄孕妇的胎儿染色体核型进行分析,对比不同年龄组与染色体异常情况的相关性。方法对1036例就诊的高龄孕妇进行羊膜穿刺术、羊水细胞培养并分析染色体核型。结果共检出异常核型69例,异常核型检出率为6.66%。在不同年龄组中,35-39岁、40岁及以上孕妇的羊水染色体异常检出率分别为5.70%、9.76%,差异具有统计学意义(P<0.05)。结论随着孕妇年龄增长,胎儿染色体异常率增加,对高龄孕妇进行产前诊断,指导临床干预具有重要意义。Objective：Analysis of the fetal chromosomal karyotype results of pregnant women with advanced age,to compare the correlation between chromosomal abnormalities and different age groups. Methods：1036 cases of advanced maternal age performed amniocentesis,cultured amniotic fluid cell and analyzed fetal chromosomal karyotype. Results：A total of 69 cases of chromosomal abnormality had been detected,the abnormal rate was 6.66%. In different age groups,35-39 years old,40 years or older,the detection rate of abnormal amniotic fluid chromosome were 5.70%,9.76%,respectively. The difference was statistically significant（P〈0.05）. Conclusion：With the increase of the age of pregnant women,the abnormality rate of fetal chromosomes increased,which was of great significance for prenatal diagnosis and guidance of clinical intervention.

关 键 词：高龄孕妇 产前诊断 羊水细胞 染色体核型 

分 类 号：R440[医药卫生—诊断学] R714.5[医药卫生—临床医学]