羊胎盘复合物对老年小鼠抗氧化作用的研究  

Antioxidant effects of composite extraction of goat placental preparations on aged mice

作　　者：郭秋平 陈贵英 周泉 GUO Qiu-Ping;CHEN Gui-Ying;ZHOU Quan(Drug Nonclinical Evaluation and Research Center of Guangzhou Pharmaceutical Research Institute, Guangzhou 510240, China)

机构地区：[1]广州医药研究总院有限公司药物非临床评价研究中心,广州510240

出　　处：《食品安全质量检测学报》2017年第9期3371-3374,共4页Journal of Food Safety and Quality

摘　　要：目的评价羊胎盘复合物的抗氧化作用。方法 ICR老年小鼠,分别以0.45、0.90和2.70 g/kg剂量连续灌胃30 d后,检测血液丙二醛(malondialdehyde,MDA)、蛋白质羰基、超氧化物岐化酶(superoxide dismutase,SOD)和还原性谷胱甘肽(glutathione,GSH)等指标评价其抗氧化功能。结果老年小鼠经口给予羊胎盘复合物30 d后,羊胎盘复合物能减少血液MDA的含量,升高GSH和SOD的含量。结论结果显示,羊胎盘复合物对老年小鼠显示了一定的抗氧化作用。Objective To evaluate the antioxidant effects of composite extraction of goat placental preparations. Methods ICR aged mice were consistently administered intragastricly with the composite extraction （0.45, 0.90 and 2.70 g/kg） for 30 days. Subsequently, function indexes including malondialdehyde （MDA）, protein carbonyl, superoxide dismutase （SOD） and glutathione （GSH） were detected. Results After oral administration of composite extraction of goat placental preparations in aged mice for 30 d, the content of MDA was decreased, and the content of GSH and SOD were increased. Conclusion The results show that the composite extraction of goat placental preparations can enhance the antioxidant function of aged mice.

关 键 词：羊胎盘 抗氧化 丙二醛 蛋白质羰基 超氧化物岐化酶 谷胱甘肽 

分 类 号：R151[医药卫生—营养与食品卫生学]