脑梗死与血脂及同型半胱氨酸水平的相关性研究  

The relationship between the level of serum lipid and homocysteine with cerebral infarction

作　　者：吴锐浩[1] 周星星[1] 周武[1] 屠鸿翔[1] 周铁丽[1] 

机构地区：[1]温州医科大学附属第一医院医学检验中心,浙江温州325000

出　　处：《预防医学》2017年第12期1231-1234,共4页CHINA PREVENTIVE MEDICINE JOURNAL

摘　　要：目的探讨脑梗死发生与同型半胱氨酸(Hcy)及血脂水平的相关性,为防制脑梗死提供参考。方法纳入2 525例脑梗死住院患者及8 151名体检正常者为研究对象,采集研究对象清晨空腹静脉血,分别采用酶循环法和酶法进行血清Hcy和血脂水平检测,根据血脂检测结果计算动脉硬化指数(ASI),采用Logistic回归模型分析脑梗死发生的危险因素。结果正常组男性4 952人,女性3 199人,平均(45.65±10.77)岁;脑梗死组男性1 590例,女性935例,平均(65.47±12.16)岁。正常组共检出高Hcy血症360人,检出率为4.42%,脑梗死组共检出高Hcy血症268人,检出率为10.61%,差异有统计学意义(P<0.01)。Logistic回归分析结果显示,高龄(OR=1.147,95%CI:1.140~1.154)、高Hcy(OR=1.022,95%CI:1.010~1.035)、高总胆固醇(OR=2.815,95%CI:2.603~3.045)、高ASI(OR=1.914,95%CI:1.794~2.042)是脑梗死发生的危险因素,女性(OR=0.694,95%CI:0.606~0.697)是脑梗死发生的保护因素。结论血清Hcy、总胆固醇水平及ASI升高可增加脑梗死的发生风险,定期检测血清Hcy及血脂水平有助于及早发现和预防脑梗死。Objective To investigate the correlation between cerebral infarction and homocysteine （Hcy ） level andatherosclerosis index（ ASI ） , and to provide reference for prevention and treatment of cerebral infarction. Methods 2 525patients hospitalized with cerebral infarction and 8 151 healthy subjects were included in the study, the blood serumhomocysteine and blood lipid levels were detected by enzymatic cycling and enzymatic method, and the ASI was calculatedaccording to the results of blood lipid test. The risk factors of cerebral infarction were analyzed by logistic regression analysismodel. Results The Physical examination Health Group male 4 952, female 3 199, average（45.65±10.77 ） years old, inthe cerebral infarction Group male1 590 cases, female 935, average（65.47±12.16） years old.A total of 360 patientswith high homocysteine were detected in the Health examination group, the detection rate was 4.42%, the cerebral infarctiongroup detected 268 patients with high homocysteine, the detection rate was 10.61%, and the difference was statisticallysignificant （P〈0.01 ） . Logistic regression analysis showed that age（OR=1.147,95%CI：1.140～1.154）, homocysteine（OR=1.022,95%CI：1.010～1.035 ） and total cholesterol（OR=2.815,95%CI：2.603～3.045） level, ASI（OR=1.914,95%CI：1.794～2.042 ） are the risk factors of cerebral infarction, women （OR=0.694,95%CI：0.606～0.697）are the protective factors for the occurrence of cerebral infarction. Conclusion Serum homocysteine and total cholesterollevels, ASI elevated can increase the risk of cerebral infarction, regular detection of serum homocysteine and lipid levels canhelp early detection and prevention of cerebral infarction.

关 键 词：脑梗死 同型半胱氨酸 血脂 动脉硬化指数 

分 类 号：R743.33[医药卫生—神经病学与精神病学]