Extracellular vesicles： novel vehicles in herpesvirus infection  

作　　者：Lingzhi Liu Quan Zhou Yan Xie Lielian Zuo Fanxiu Zhu Jianhong Lu 

机构地区：[1]The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410080, China [2]Cancer Research Institute, Central South University, Changsha 410078, China [3]Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China [4]Department of Microbiology, School of Basic Medical Science, Central South University, Changsha410078, China [5]Department of Biological Science, Florida State University, Tallahassee 32306, USA

出　　处：《Virologica Sinica》2017年第5期349-356,共8页中国病毒学（英文版）

基　　金：supported by the National Natural Science Foundations of China (81372139, 31670171, 81728011);the National Key Research and Development Program of China (2017YFC1200204);the Hunan Provincial Natural Science Foundation of China (2015JJ2149)

摘　　要：Herpesviruses are remarkable pathogens that have evolved multiple mechanisms to evade host immunity, ensuring their proliferation and egress. Among these mechanisms, herpesviruses utilize elaborate extracellular vesicles, including exosomes, for the intricate interplay between infected host and recipient cells. Herpesviruses incorporate genome expression products and direct cellular products into exosomal cargoes. These components alter the content and function of exosomes released from donor cells, thus affecting the downstream signalings of recipient cells. In this way, herpesviruses hijack exosomal pathways to ensure their survival and persistence, and exosomes are emerging as critical mediators for virus infection-associated intercellular communication and microenvironment alteration. In this review, the function and effects of exosomes in herpesvirus infection will be discussed, so that we will have a better understanding about the pathogenesis of herpesviruses.Herpesviruses are remarkable pathogens that have evolved multiple mechanisms to evade host immunity, ensuring their proliferation and egress. Among these mechanisms, herpesviruses utilize elaborate extracellular vesicles, including exosomes, for the intricate interplay between infected host and recipient cells. Herpesviruses incorporate genome expression products and direct cellular products into exosomal cargoes. These components alter the content and function of exosomes released from donor cells, thus affecting the downstream signalings of recipient cells. In this way, herpesviruses hijack exosomal pathways to ensure their survival and persistence, and exosomes are emerging as critical mediators for virus infection-associated intercellular communication and microenvironment alteration. In this review, the function and effects of exosomes in herpesvirus infection will be discussed, so that we will have a better understanding about the pathogenesis of herpesviruses.

关 键 词：HERPESVIRUSES extracellular vesicles(EVs) INFECTION PATHOGENESIS 

分 类 号：R373.11[医药卫生—病原生物学]