Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral Clavularia viridis  

作　　者：GAO Yuan XIAO Wei LIU Hong-Chun WANG Jian-Rong YAO Li-Gong OUYANG Ping-Kai WANG De-Cai GUO Yue-Wei 

机构地区：[1]College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China [2]jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222002, China [3]State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203,China

出　　处：《Chinese Journal of Natural Medicines》2017年第11期855-859,共5页中国天然药物（英文版）

基　　金：supported by the Natural Science Foundation of China(Nos.81520108028,21672230,41506187,and 816013016);the SKLDR/SIMM Project(No.SIMM1501ZZ-03)

摘　　要：In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B(1), and A(2), along with three known sesquiterpenes(3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3–5 were evaluated for their cytotoxic activity.In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B（1）, and A（2）, along with three known sesquiterpenes（3-5）, were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3-5 were evaluated for their cytotoxic activity.

关 键 词：Soft CORAL Clavularia VIRIDIS Trinor-guaiane SESQUITERPENE CYTOTOXIC activity 

分 类 号：R284[医药卫生—中药学]