高肺血流量对大鼠肺腺泡内动脉超微结构的影响  

Influence of high pulmonary blood flow on ultrastructure of intra-acinar pulmonary arteries in rats

作　　者：齐建光[1] 汤秀英[2] 杜军保[1] 张烨[2] 柴立军[2] 唐朝枢[3] 

机构地区：[1]北京大学第一医院儿科,北京100034 [2]北京大学第一医院电镜室,北京100034 [3]北京大学第一医院心血管病研究所,北京100034

出　　处：《电子显微学报》2002年第4期380-382,共3页Journal of Chinese Electron Microscopy Society

基　　金：北京大学生物医学跨学科研究项目;国家重点基础研究发展规划 (973项目 )资助项目

摘　　要：为探讨高肺血流量对大鼠肺腺泡内动脉超微结构的早期影响 ,对大鼠行腹主动脉 下腔静脉分流术。术后6周以右心导管法测定肺动脉平均压 ,透射电镜观察肺腺泡内动脉超微结构变化。结果显示 ,分流组大鼠肺动脉平均压明显增高。超微结构观察 ,肺腺泡内动脉内皮细胞增生、变性 ;内弹力层粗细不均 ;平滑肌细胞增生及血管周细胞增生。电镜观察结果提示 。To study the influence of high pulmonary blood flow on ultrastructure of intra acinar pulmonary arteries, abdominal aorta and inferior vena cava shunting was produced in shunting rats. After 6 weeks shunting, the mean pressure of pulmonary artery of experimental rats was evaluated by using a right cardiac catheterization procedure. Ultrastructure of intra acinar pulmonary arteries was observed by transmission electron microscopy. The results showed that the mean pressure of pulmonary artery was significantly increased after 6 weeks aortocaval shunting. Ultrastructurally, the endothelial cells of intra acinar pulmonary arteries of shunting rats appeared hyperplasia and degenerated. The internal elastic laminar was irregular. The smooth muscle cells were hypertrophy. The pericytes were hyperplasia. The results suggested that pulmonary vascular structural remodeling is the important pathologic basis of pulmonary hypertension induced by a left to right shunt.

关 键 词：高肺血流量 肺腺泡内动脉 超微结构 左向右分流 大鼠 先天性心脏病 肺血管 

分 类 号：R361[医药卫生—病理学]