热带假丝酵母唑类耐药相关基因的研究进展  

Progress on azole resistance-related genes in Candida tropicalis

作　　者：唐娜 郭大文[1] 

机构地区：[1]哈尔滨医科大学附属第一医院检验科,哈尔滨150001

出　　处：《微生物与感染》2017年第6期381-384,共4页Journal of Microbes and Infections

摘　　要：临床上热带假丝酵母(又称热带念珠菌)的分离率越来越高,唑类抗真菌药物因较低的细胞毒性且大多可口服给药,是治疗热带念珠菌感染的常用药物。我国耐唑类药物热带念珠菌的分离率较高,因此有必要了解其具体机制,为寻求新的药物作用靶点提供依据。目前认为,与热带念珠菌唑类耐药有关的主要机制有靶基因ERG11过度表达和突变、编码转录因子的upc2基因过度表达和突变、外排泵基因过度表达及其他相关基因过度表达等。本文就目前热带念珠菌唑类耐药机制的基因水平研究进展进行综述。Detection rate of Candida tropicalis（C.tropicalis）is increasing in clinical practice.Azole antifungal agents are commonly used in the treatment of C.tropicalis infection because of their low cytotoxicity and oral administration.In China,there is a high rate of isolation of azole resistant C.tropicalis.It is necessary to understand the azole resistance mechanism of C.tropicalis,which may provide a base for new drug targets.At present,the main mechanisms associated with resistance of C.tropicalis to azoles are the overexpression and mutation of the target gene ERG11,the overexpression and mutation of upc2 gene encoding a transcription factor,the overexpression of efflux pump genes and other related genes.In this paper,the current progress on the latest azole resistance mechanism of C.tropicalis is reviewed.

关 键 词：热带假丝酵母 ERG11基因 唑类耐药 基因突变 

分 类 号：R446.5[医药卫生—诊断学]