洛铂联合香菇多糖与单用洛铂治疗恶性胸腔积液疗效比较  

Comparison on efficacy of malignant pleural effusion treated by losoplatin combined with lentinan and single losoplatin

作　　者：周琰[1] 

机构地区：[1]天津医科大学总医院,300052

出　　处：《中国实用医药》2017年第35期4-6,共3页China Practical Medicine

摘　　要：目的比较洛铂联合香菇多糖与单用洛铂治疗恶性胸腔积液的疗效。方法 52例恶性胸腔积液患者,随机分为观察组及对照组,各26例。观察组给予洛铂联合香菇多糖治疗,对照组单用洛铂治疗。比较两组治疗效果。结果观察组总有效率为80.8%,高于对照组的53.8%,差异具有统计学意义(P<0.05)。观察组卡氏(KPS)评分稳定率为88.5%,高于对照组的65.4%,差异具有统计学意义(P<0.05)。两组患者不良反应比较,差异无统计学意义(P>0.05)。结论洛铂联合香菇多糖胸腔灌注治疗恶性胸腔积液效果理想,不良反应轻,可进行推广。Objective To compare the efficacy of malignant pleural effusion treated by losoplatin combined with lentinan and single losoplatin. Methods A total of 52 malignant pleural effusion patients were randomly divided into observation group and control group, with 26 cases in each group. The observation group was treated with losoplatin combined with lentinan, and the control group was treated with single losoplatin. The treatment effects in two groups was compared. Results The observation group had higher total effective rate as 80.8% than 53.8% in the control group, and the difference was statistically significant（P〈0.05）. The observation group had higher stability of Karnofsky（KPS） score as 88.5% than 65.4% in the control group, and the difference was statistically significant（P〈0.05）. Both groups had no statistically significant difference in adverse reactions（P〉0.05）. Conclusion Combination of losoplatin and lentinan shows ideal effect in treating malignant pleural effusion with light adverse reactions, and it can be promoted.

关 键 词：洛铂 香菇多糖 恶性胸腔积液 

分 类 号：R730.5[医药卫生—肿瘤]