保乳手术与改良根治术对早期乳腺癌患者血清CEA,CA15-3及TPA水平的影响及临床疗效  

Effects of Breast Conserving Surgery and Modified Radical Mastectomy on Serum Levels of CEA, CA15-3 and TPA in Patients with Early Breast Cancer

作　　者：刘莹[1] 胡杰[1] 杨磊[1] 汪正燕 荣薇[1] 熊斌[2] 

机构地区：[1]遂宁市中心医院甲乳外科,四川遂宁629000 [2]川北医学院附属医院甲乳外科,四川南充637000

出　　处：《现代生物医学进展》2017年第35期6865-6868,共4页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研基金项目(130445)

摘　　要：目的:探讨保乳手术与改良根治术对早期乳腺癌患者血清CEA,CA15-3及TPA水平的影响及其临床疗效。方法:选取我院收治的乳腺癌患者68例,按照手术方式不同将患者随机分为保乳手术组和改良手术组,每组34例。保乳手术组患者采用乳腺癌保乳手术治疗,改良手术组患者采用改良根治术治疗。观察并比较两组患者的临床有效率、并发症发生率、术后复发率、转移率、生存率以及血清CEA,CA15-3及TPA水平的变化情况。结果:改良手术组总有效率及5年生存率均优于保乳手术组(P<0.05);保乳手术组并发症、局部复发率、肿瘤远处转移率均低于改良手术组(P<0.05);治疗后两组患者血清CEA、CA15-3、TPA水平均降低,且改良手术组低于保乳手术组(P<0.05)。结论:保乳手术与改良根治术均能有效治疗早期乳腺癌,但保乳手术效果优于改良根治术,不仅能够降低患者血清CEA,CA15-3及TPA水平,而且并发症及复发率较低。Objective： To investigate the effect of breast conserving surgery and modified radical mastectomy on serum levels of CEA, CA15-3 and TPA in patients with early breast cancer. Methods： 68 patients with breast cancer who were treated in our hospital were selected, and according to the different surgery methods, the patients were randomly divided into the breast conserving surgery group and the modified radical mastectomy group, with 34 cases in each group. The patients in the breast conserving surgery group were treated with breast conserving surgery, while the patients in the modified radical mastectomy group were treated with modified radical mastectomy. Then the clinical effective rate, the complications, the postoperative recurrence rate, metastasis rate, survival rate and the serum levels of CEA, CA15-3 and TPA of patients in the two groups were observed and compared before and after the treatment. Results： The total effective rate and 5-years＇ survival rate of the modified radical mastectomy group were better than those of the breast conserving surgery group （P〈0.05）; The complications, local recurrence rate and tumor distant metastasis rate of the breast conserving surgery group were lower than those of the modified radical mastectomy group （P〈0.05）; The serum levels of CEA, CA15-3 and TPA of the two groups decreased after treatment, and the modified radical mastectomy group were lower than those of the breast conserving surgery group （P〈0.05）. Conclusion： Breast conserving surgery and modified radical mastectomy can effectively treated early breast cancer, while breast conserving surgery effect is slightly better than the modified radical mastectomy, which can reduce the serum levels of CEA, CA15-3 and TPA, and decrease the rates of complications and recurrence.

关 键 词：乳腺癌 保乳手术 改良根治术 CEA CA15-3 TPA 

分 类 号：R737.9[医药卫生—肿瘤]