Electroacupuncture improves neurovascular unit reconstruction by promoting collateral circulation and angiogenesis  

作　　者：Lei Shi Hong-mei Cao Ying Li Shi-xin Xu Yan Zhang Yang Zhang Zhe-feng Jin 

机构地区：[1]First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China [2]National Engineering Research Center for Beijing Biochip Technology, Beijing, China [3]Shaanxi University of Chinese Medicine, Xianyang, Shaanxi jzrovince, China

出　　处：《Neural Regeneration Research》2017年第12期2000-2006,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81303021

摘　　要：Acupuncture at Shuigou（GV26） shows good clinical efficacy for treating stroke, but its mechanism remains poorly understood. In this study, a cerebral infarction model of ischemia/reperfusion injury received electroacupuncture at GV26（15 Hz and 1 m A, continuous wave [biphasic pulses], for 5 minutes）. Electroacupuncture effectively promoted regional cerebral blood flow on the infarct and non-infarct sides, increased infarct lesions, lectin, and number of blood vessels, upregulated von Willebrand factor and cell proliferation marker Ki67 expression, and diminished neurological severity score. These findings confirm that electroacupuncture at GV26 promotes establishment of collateral circulation and angiogenesis, and improves neurological function.Acupuncture at Shuigou（GV26） shows good clinical efficacy for treating stroke, but its mechanism remains poorly understood. In this study, a cerebral infarction model of ischemia/reperfusion injury received electroacupuncture at GV26（15 Hz and 1 m A, continuous wave [biphasic pulses], for 5 minutes）. Electroacupuncture effectively promoted regional cerebral blood flow on the infarct and non-infarct sides, increased infarct lesions, lectin, and number of blood vessels, upregulated von Willebrand factor and cell proliferation marker Ki67 expression, and diminished neurological severity score. These findings confirm that electroacupuncture at GV26 promotes establishment of collateral circulation and angiogenesis, and improves neurological function.

关 键 词：nerve regeneration ischemic cerebral infarction ISCHEMIA/REPERFUSION ELECTROACUPUNCTURE Shuigou （GV26） collateral circulation ANGIOGENESIS neural regeneration 

分 类 号：R245[医药卫生—针灸推拿学]