伴晨重夕轻节律的抑郁发作患者视交叉上核功能连接特征研究  

Functional connectivity of suprachiasmatic nucleus in major depressive episodes patients with morn-ing heavy night light rhythm

作　　者：耿纪婷 阎锐[1] 莫昭奇 陈瑜[1] 史家波[1] 卢青[2] 姚志剑[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,南京210029 [2]东南大学生物科学与医学工程学院儿童发展与学习科学教育部重点实验室,南京210096

出　　处：《中华行为医学与脑科学杂志》2017年第12期1081-1085,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81571639,81371522,61372032）;国家高技术研究发展计划项目（863计划）（2015AA020509）;江苏省科技强卫青年医学人才项目（QNRC2016050）;南京市科技发展计划项目（YKK15110）

摘　　要：目的 探讨伴晨重夕轻节律的抑郁发作患者视交叉上核（suprachiasmatic nucleus, SCN）功能连接的改变.方法 招募44例伴晨重夕轻节律的抑郁发作患者（节律组）、58例不伴晨重夕轻节律的抑郁发作患者（非节律组）和56位性别、年龄及受教育年限均匹配的健康对照,进行3.0 T静息态磁共振扫描.以SCN为感兴趣区（region of interest,ROI）,计算所有被试ROI与全脑的功能连接（functional connectivity,FC）值,在方差分析的基础上进行两两独立样本t检验,将两组患者差异脑区FC值与节律组临床症状严重程度进行相关分析.结果 三组受试SCN与左内侧额上回（MNI：x=0,y=39,z=51;K=14）、右小脑脚1区（MNI：x=39,y=-48,z=-36;K=18）FC值存在差异（P〈0.05,Al-phasim矫正）.与非节律组相比,节律组SCN与左内侧额上回及右三角部额下回（MNI：x=39,y=27, z=27;K=10）FC值升高（P〈0.05,Alphasim矫正）.与健康对照组相比,非节律组SCN与左内侧额上回FC值降低（P〈0.05,Alphasim矫正）.相关分析发现SCN与左内侧额上回FC值与绝望感因子呈正相关（r=0.31,P=0.041）.结论 伴晨重夕轻节律的抑郁症发作患者SCN与前额叶活动的协同性增加,可能参与昼夜节律的形成机制.Objective To explore the variations of functional connectivity in depressive episode pa-tients with diurnal rhythm.Methods Totaly 44 patients with depressive episode with diurnal rhythm（rhythm group）,58 patients with depressive episode without diurnal rhythm（non-rhythm group）and 56 matched healthy volunteer controls（healthy group）were scanned with 3.0 T MRI Scanner.Functional connectivity （FC）were calculated between suprachiasmatic nucleus（SCN）and whole brain regions.According to results of ANOVA,group-wise two sample t-test was completed.Correlation analysis were conducted between FC of significant difference brain regions and the score of Hamilton rating scale（HAMD-24）for depression.Results The brain regions showing differences among three groups were located in the left medial superior frontal gy-rus（MNI：x=0,y=39,z=51; K=14）and right cerebellum crus 1（MNI：x=39,y=-48,z=-36; K=18） （P〈0.05,Alphasim）.Compared with non-rhythm group,the FC of rhythm group showed significantly in-creased in the left medial superior frontal gyrus and right triangular inferior frontal gyrus（MNI：x=39,y=27, z=27;K=10）（P〈0.05,Alphasim）.Compared with healthy group,the FC of non-rhythm group showed sig-nificantly decreased in left medial superior frontal gyrus（P〈0.05,Alphasim）.Positive correlation was found be-tween FC in left medial superior frontal gyrus and despair score of HAMD-24（r= 0.31,P= 0.041）. Conclusion The synergistic increase in SCN and prefrontal activity in patients with depressive episodes with morning heavy night light rhythm which may be involved in the formation mechanism of the diurnal rhythm.

关 键 词：抑郁发作 晨重夕轻 功能磁共振 视交叉上核 功能连接 

分 类 号：R749.4[医药卫生—神经病学与精神病学]