Camptothecin-based nanodrug delivery systems  

作　　者：Yan Wen Yingze Wang Xiaoli Liu Wei Zhang Xinhe Xiong Zhongxiao Han Xingjie Liang 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China [2]University of Chinese Academy of Sciences, Beijing 100049, China [3]College of Biological Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China [4]Department of Materials Science and Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32611, USA [5]School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 220096, China

出　　处：《Cancer Biology & Medicine》2017年第4期363-370,共8页癌症生物学与医学（英文版）

摘　　要：The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer,rectal and colon cancer,liver cancer,and lung cancer.Camptothecin-based drugs inhibit topoisomerase 1(Topo 1),leading to destruction of DNA,and are currently being used as important chemotherapeutic agents in clinical antitumor treatment.However,the main obstacle associated with cancer therapy is represented by systemic toxicity of conventional anticancer drugs and their low accumulation at the tumor site.In addition,low bioavailability,poor water solubility,and other shortcomings hinder their anticancer activity.Different from traditional pharmaceutical preparations,nanotechnology-dependent nanopharmaceutical preparations have become one of the main strategies for different countries worldwide to overcome drug development problems.In this review,we summarized the current hotspots and discussed a variety of camptothecin-based nanodrugs for cancer therapy.We hope that through this review,more efficient drug delivery systems could be designed with potential applications in clinical cancer therapy.The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon cancer, liver cancer, and lung cancer. Camptothecin-based drugs inhibit topoisomerase 1 （Topo 1）, leading to destruction of DNA, and are currently being used as important chemotherapeutic agents in clinical antitumor treatment. However, the main obstacle associated with cancer therapy is represented by systemic toxicity of conventional anticancer drugs and their low accumulation at the tumor site. In addition, low bioavailability, poor water solubility, and other shortcomings hinder their anticancer activity. Different from traditional pharmaceutical preparations, nanotechnology-dependent nanopharmaceutical preparations have become one of the main strategies for different countries worldwide to overcome drug development problems. In this review, we summarized the current hotspots and discussed a variety of camptothecin-based nanodrugs for cancer therapy. We hope that through this review, more efficient drug delivery systems could be designed with potential applications in clinical cancer therapy.

关 键 词：CAMPTOTHECINS NANOMEDICINE cancer therapy drug delivery system 

分 类 号：R730.5[医药卫生—肿瘤]