CAMPTOTHECINS

作品数：4被引量：5H指数：1
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Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts被引量：1
《Cancer Drug Resistance》2019年第4期1153-1163,共11页Evan J.Brettrager Robert C.A.M.van Waardenburg 
RCAMvW was in part funded by American Cancer Society UAB ACS-IRG Junior Faculty Development Grant(ACS-IRG-60-001-53);Department of Defense OCRP pilot award W81XWH-15-1-0198;the National Institutes of Health Cancer Center Core Support Grant(P30CA013148).
Our genomic DNA is under constant assault from endogenous and exogenous sources,which needs to be resolved to maintain cellular homeostasis.The eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I(Tdp1)catalyz...
关键词：Tdp1 small molecules DNA topoisomerases CAMPTOTHECINS oxidative DNA damage DNA adducts ETOPOSIDE chain terminating nucleotides/nucleoside analogs DNA metabolism drug development 
Camptothecin-based nanodrug delivery systems被引量：3
《Cancer Biology & Medicine》2017年第4期363-370,共8页Yan Wen Yingze Wang Xiaoli Liu Wei Zhang Xinhe Xiong Zhongxiao Han Xingjie Liang 
The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer,rectal and colon cancer,liver cancer,and lung cancer.Camptothecin-based drugs inhibit topoisomerase 1(Topo 1),leading to ...
关键词：CAMPTOTHECINS NANOMEDICINE cancer therapy drug delivery system 
Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S)-camptothecins被引量：1
《Chinese Chemical Letters》2008年第10期1202-1205,共4页Di Zao Li Xian Dao Pan Hong Yan Liu Song Wu 
A series of 5-C-alkylating camptothecins have been synthesized by one-step method, and their in vitro antitumor activity was evaluated against six human cancer cell lines. The results showed that all 5-C-alkylates of ...
关键词：CAMPTOTHECIN SYNTHESIS 5-C-Alkylate Antitumor activity 
Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins
《Chinese Chemical Letters》2007年第11期1335-1338,共4页Di Zao Li Yan Li Xiao Guang Chen Chen Gen Zhu Jing Yang Hong Yan Liu Xian Dao Pan 
A series of heterocyclic acid esters of camptothecins as new compounds had been synthesized by acylation method, their in vitro and in vivo antitumor activities were evaluated. The cytotoxic results showed that 6 poss...
关键词：CAMPTOTHECIN SYNTHESIS Heterocyclic acid Antitumor activity 
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