Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses  

作　　者：Li-Hua Gong Wei-Feng Liu Yi Ding Yue-Hang Geng Xiao-Qi Sun Xiao-Yuan Huang 

机构地区：[1]Department of Pathology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100035, China [2]Department of Orthopedic Oncology,Beijing Jishuitan Hospital, The Fourth Medical-College of Peking University, Beijing 100035, China [3]Department of Pathology, Peking University Health Science Center, Beijing 100191, China

出　　处：《Chinese Medical Journal》2018年第1期32-36,共5页中华医学杂志（英文版）

摘　　要：Background： Desmoplastic fibroblastoma （collagenous fibroma） is an uncommon benign soft-tissue tumor, rarely involving bone. It shares some overlapping features with other infiltrate tumors, such as desmoid-type fibromatosis, neurofibroma, and low-grade fibromyxoid sarcoma. The misdiagnosis may cause unnecessary surgical overtreatment, especially for those involving bone. In order to deepen the understanding of the diagnosis and differential diagnosis of desmoplastic fibroblastoma, we planned to analyze the clinical, radiological, and histopathological features and the outcome of desmoplastic fibroblastoma on the basis of case analysis and literature review. Methods： Sixteen cases were retrieved from the surgical pathology records from May 2011 to April 2016 in the Department of Pathology in Beijing Jishuitan Hospital. Formalin-fixed, paraffin-embedded specimens of 16 cases of desmoplastic fibroblastoma were collected. Hematoxylin and eosin stain and immunohistochemistry were used to observe the histological features of desmoplastic fibroblastoma of soft tissue and bone. The images for diagnosis obtained from the ultrasonic examination, X-ray, magnetic resonance imaging, and computed tomography were used to observe the radiological features. Related literatures were retrieved from the PubMed and CNKI databases. Results： Sixteen cases of desmoplastic fibroblastoma of soft tissue were located in the hand （n = 7）, loot （n = 4）, upper arm （n = 1）, shoulder （n = 1）, forearm （n = 2）, and one case occurred in the proximal femur. Age ranged from 32 to 82 years （median age： 58 years）. There were six females and ten males. Histologically, the lesions of soft tissue appeared as well-circumscribed masses with abundant collagenous matrix and low vascularity. Tumor cells were stellate- or spindle-shaped and uniformly distributed within the extracellular matrix. In five cases, the desmoplastic fibroblastoma were found to have infiltrated into the skeletal muscle tissue. In one case ofdesmoplaBackground： Desmoplastic fibroblastoma （collagenous fibroma） is an uncommon benign soft-tissue tumor, rarely involving bone. It shares some overlapping features with other infiltrate tumors, such as desmoid-type fibromatosis, neurofibroma, and low-grade fibromyxoid sarcoma. The misdiagnosis may cause unnecessary surgical overtreatment, especially for those involving bone. In order to deepen the understanding of the diagnosis and differential diagnosis of desmoplastic fibroblastoma, we planned to analyze the clinical, radiological, and histopathological features and the outcome of desmoplastic fibroblastoma on the basis of case analysis and literature review. Methods： Sixteen cases were retrieved from the surgical pathology records from May 2011 to April 2016 in the Department of Pathology in Beijing Jishuitan Hospital. Formalin-fixed, paraffin-embedded specimens of 16 cases of desmoplastic fibroblastoma were collected. Hematoxylin and eosin stain and immunohistochemistry were used to observe the histological features of desmoplastic fibroblastoma of soft tissue and bone. The images for diagnosis obtained from the ultrasonic examination, X-ray, magnetic resonance imaging, and computed tomography were used to observe the radiological features. Related literatures were retrieved from the PubMed and CNKI databases. Results： Sixteen cases of desmoplastic fibroblastoma of soft tissue were located in the hand （n = 7）, loot （n = 4）, upper arm （n = 1）, shoulder （n = 1）, forearm （n = 2）, and one case occurred in the proximal femur. Age ranged from 32 to 82 years （median age： 58 years）. There were six females and ten males. Histologically, the lesions of soft tissue appeared as well-circumscribed masses with abundant collagenous matrix and low vascularity. Tumor cells were stellate- or spindle-shaped and uniformly distributed within the extracellular matrix. In five cases, the desmoplastic fibroblastoma were found to have infiltrated into the skeletal muscle tissue. In one case ofdesmopla

关 键 词：Bone COLLAGENOUS DESMOPLASTIC Diagnosis Differential FIBROMA lmmunohistochemistry Soft Tissue 

分 类 号：R0[医药卫生]