Activity of metalloproteinases and adiponectin in obese patients——a possible factor of incisional hernias after bariatric procedures  

肥胖患者体内金属蛋白酶和脂联素的活性——肥胖手术后造成切口疝的可能因素（英文）

作　　者：Wojciech SZCZESNY Magdalena KULIGOWSKA-PRUSINSKA Stanislaw DABROWIECKI Jakub SZMYTKOWSKI Adrian RESLINSKI Maciej SLUPSKI 

机构地区：[1]Ludwik Rydygier College of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2018年第1期65-70,共6页浙江大学学报（英文版）B辑（生物医学与生物技术）

摘　　要：Purpose： Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2（MMP-2）, MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls. Materials and methods： The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups： I（body mass index（BMI）≥35 kg/m^2, n=40） and II（BMI〈25 kg/m^2, n=30）. Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay（ELISA）. Results： A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. Conclusions： The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.目的:主要研究病态肥胖患者与正常人血清中金属蛋白酶2(MMP-2)、MMP-9、MMP-13和脂联素的浓度。创新点:建立血清中MMP-2、MMP-9、MMP-13和脂联素的浓度与肥胖和切口疝的关系。方法:参与实验的人员为进行肥胖手术的患者和不进行肥胖手术的患者,并将他们分为两组:I(体重指数(BMI)≥35 kg/m2,n=40)和I(IBMI<25 kg/m2,n=30),并使用酶联免疫吸附实验测定受试人员体内血清中MMP-2、MMP-9、MMP-13和脂联素的浓度。结论:MMP-2的浓度在肥胖组中更高,且在两组血清中有显著性差异。虽然MMP-9的浓度在肥胖组中更高,但是两组之间没有显著性差异。MMP-13在两组间没有差异。血清中脂联素的浓度在非肥胖组更高,但无显著性差异。因此,血清中MMP-2和MMP-9的浓度在肥胖人群中与更高的切口疝发病率有关。

关 键 词：METALLOPROTEINASE ADIPONECTIN OBESITY Incisional hernia 

分 类 号：R656.2[医药卫生—外科学]