新型喹喔啉类化合物的合成及结构表征  

Synthesis and Characterization of Novel Quinoxaline Derivatives

作　　者：林锦 薛国震 王艰[1] 许秀枝[1] 李柱来[1] 

机构地区：[1]福建医科大学药学院药物化学系,福州350122

出　　处：《海峡药学》2018年第2期38-40,共3页Strait Pharmaceutical Journal

摘　　要：目的合成一系列2,3-二取代喹喔啉类化合物并确证其化学结构。方法以邻苯二胺为起始底物,通过环合、氯化、偶联等五步反应合成多种2,3-二取代喹喔啉类化合物。测定目标化合物的物理常数,并通过多种波谱分析技术(核磁共振氢谱、红外光谱、质谱)对其结构进行表征。结果以较高的产率(五步反应17%的总产率)制备多种2,3-二取代喹喔啉类化合物,经核磁共振氢谱及质谱等多种波谱手段确证为目标化合物。结论该方法过程简便,产率较高,为未来的抗肿瘤活性实验提供有力的支持。OBJECTIVE A series of 2,3-disubstituted quinoxaline derivatives have been synthesized and their structures have been characterized. METHODS With o-phenylenediamine as the starting material,a series of 2,3-disubstituted quinoxaline derivatives have been yielded through 5 steps reaction involving cyclization,chlorination and coupling etc. The physical constants of target compounds were determined,and their structures were characterized using various spectra techniques（^1H-NMR,IR,MS）. RESULTS 2,3-disubstituted quinoxaline derivatives were prepared with a relatively higher yield（ total yield of 17% for five steps reaction）,which were proved as target compounds by usingvariousspectra techniques such as 1 H-NMR and MSetc. CONCLUSION The synthetic route,with simple process and good yield,substantially supports the antitumor study in the future.

关 键 词：喹喔啉 合成 表征 

分 类 号：TQ460.4[化学工程—制药化工]