洋葱多肽对四氧嘧啶糖尿病小鼠的影响  

The effects of onion polypeptide on glucose level in alloxan-induced diabetic mice

作　　者：谭珺隽 曹聪 柯尊军 高其双 彭霞 周华 刘阳[2] TAN Jun-jun1, CAO Cong2, KE Zun-jun2, GAO Qi-shuang1, PENG Xia1, ZHOU Hua1, LIU Yang2(1 .Wuhan Institute of Animal Husbandry and Veterinary Science, Wuhan Acadmy of Agricultural Sciences, Wuhan 430208; 2.Synergy Innovation Center of Biological Polypetide Antidiabetics of Hubei Province, School of Life Science, Wuchang University of Technology, Wuhan 43000)

机构地区：[1]武汉市农业科学技术研究院,畜牧兽医科学研究所,武汉430208 [2]武昌理工学院生命科学学院,生物多肽糖尿病药物湖北省协同创新中心,武汉430000

出　　处：《食品科技》2018年第3期223-226,共4页Food Science and Technology

基　　金：湖北省自然科学基金项目(2016CFB295).

摘　　要：目的:探讨洋葱提取物多肽对四氧嘧啶造模糖尿病小鼠体重、血糖及糖化血红蛋白的影响。方法:采用腹腔注射四氧嘧啶(ALX)方法建立糖尿病小鼠模型,将建模成功的小鼠分为4组:健康组、糖尿病组和洋葱多肽高、低剂量处理组。其中健康组无任何处理,糖尿病组为四氧嘧啶建模后无其他处理,洋葱多肽组在四氧嘧啶建模小鼠上进行给药。比较各组小鼠的体重变化、空腹血糖(FBG)、肾脏组织SOD、MDA等指标的差异。结果:洋葱多肽高剂量处理组显著降低模型小鼠的血糖(FBG)和肾脏组织SOD、MDA值,表明对肾脏有所修复。结论:洋葱多肽能缓解糖尿病小鼠高血糖。Objective： To study the effects of onion extract polypeptide on weight, blood glucose and glycosylated hemoglobin of alloxan-induced diabetic mice. Methods： The diabetic mice model was established by intraperitoneal injection of alloxan （ALX）. The mice were divided into 4 groups： healthy group, diabetes group, onion polypeptide high, and low dose treatment group. The diabetic group was treated with alloxan, and the onion polypeptide group was administered on alloxan-molded mice. The changes of body weight, fasting blood glucose （FBG）, kidney tissue SOD, MDA and other indexes were compared. Results： The adiponectin-induced hyperglycemia （FBG） was significantly reduced in the high-dose treatment group, and the kidney tissue SOD, MDA in diabetic mice was effectively reduced.Conclusion： Onion polypeptide can alleviate hyperglycemia in diabetic mice.

关 键 词：洋葱 多肽 四氧嘧啶 降血糖 

分 类 号：R963[医药卫生—微生物与生化药学]