制剂用水蛭原粉掩味前后主要腥臭异味物质的变化分析  

Analysis on Changes of Main Stench Compounds from Hirudo Raw Powder in Traditional Chinese Medicine Preparations Before and After Being Taste-masked

作　　者：范建伟 刘武占 李艳芳 苏瑞强 FAN Jian-wei, LIU Wu-zhan, LI Yan-fang, SU Rui-qiang(Shandong Provincial Key Laboratory of New Manufacture Technology of Traditional Chinese Medicine （TCM） , State Key Laboratory of Generic Manufacture Technology of TCM, Lunan Pharmaceutical Group Co. Ltd. , Linyi 276006, China)

机构地区：[1]鲁南制药集团股份有限公司中药制药共性技术国家重点实验室山东省中药制药新技术重点实验室

出　　处：《中国实验方剂学杂志》2018年第6期22-25,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山东省自主创新及成果转化专项(创新型产业集群)计划项目(2015ZDJQ05003)

摘　　要：目的：探讨应用β-环糊精包合技术掩蔽制剂用水蛭原粉腥臭异味的作用及效果。方法：在通过气相色谱法验证β-环糊精对正己醛、三甲胺2种成分的包合作用基础上,分析水蛭原粉经β-环糊精掩味处理前后正己醛、三甲胺的溶出变化情况。结果：正己醛、三甲胺作为水蛭原粉中腥臭异味物质的主要组成成分,其质量分数分别为0.02,0.09 mg·g-1;正己醛包合物水相中未检出正己醛成分,同样三甲胺包合物水相中仅能检出微量三甲胺;水蛭原粉与β-环糊精共研磨后所得水蛭混合粉水相中均未检出游离的正己醛和三甲胺成分。结论：β-环糊精能对正己醛、三甲胺等低分子腥臭异味成分达到有效包合作用。β-环糊精可用作气味掩蔽剂,在生产中合理添加后可达到有效掩蔽药材原粉及其制剂不良气味的目的。Objective： To discuss the function and effect on the application of β-cyclodextrin to mask the smell of stench in Hirudo raw powder. Method： GC analysis was used to test the inclusion effect of β-cyclodextrin on hexanal and trimethylamine,respectively. And dissolution changes of hexanal and trimethylamine in Hirudo raw powder before and after being treated with β-cyclodextrin were analyzed by GC. Result： Hexanal and trimethylamine were attributed to the main stench compounds in Hirudo raw powder,and their contents were 0. 02,0. 09 mg·g-1,respectively. Hexanal and trimethylamine were not detected in aqueous phases of hexanal inclusion complex with β-cyclodextrin, and only trace trimethylamine was detected in aqueous phases of trimethylamine inclusion complex with β-cyclodextrin. Meanwhile,both of free hexanal and trimethylamine were not detected in aqueous phases of mixed Hirudo powder by co-grinding with β-cyclodextrin. Conclusion： As representative of low molecular stench components,hexanal and trimethylamine can be efficiently included with β-cyclodextrin,and β-cyclodextrin can be applied as an odor masking agent to effectively mask unpleasant smells in traditional Chinese medicine preparations when added properly in the production.

关 键 词：水蛭 气相色谱法 正己醛 三甲胺 β-环糊精 气味掩蔽剂 

分 类 号：R22[医药卫生—中医基础理论] R289[医药卫生—中医学]