Roles of flotillins in tumors  

脂筏标记蛋白flotillins在肿瘤中的研究进展（英文）

作　　者：Xu-xu LIU Wei-dong LIU Lei WANG Bin ZHU Xiao SHI Zi-xuan PENG He-cheng ZHU Xing-dong LIU Mei-zuo ZHONG Dan XIE Mu-sheng ZENG Cai-ping REN 

机构地区：[1]Cancer Research Institute Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, Central South University, Changsha 410078, China [2]Changsha Kexin Cancer Hospital Changsha 410205, China [3]State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2018年第3期171-182,共12页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the National Natural Science Foundation of China(Nos.81773179 and 81272972);the National Basic Research Program(973)of China(No.2010CB833605);the Hunan Provincial Science and Technology Department(Nos.2013FJ4010 and2014FJ6006);the Open-End Fund for the Valuable and Precision Instruments of Central South University(Nos.CSUZC201634 and CSUZC201638);the Natural Science Foundation of Hunan Province(No.2016JJ2172);the National College Students Innovation Projects(Nos.201610533264 and 201610533538),China

摘　　要：The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper understanding of oncogenic proteins is needed for the benefit to cancer patients. The lipid raft marker proteins, flotillin-1 and flotillin-2, were first found in goldfish retinal ganglion cells during axon regeneration. They have since been found in a variety of cells, mainly on the inner surface of cell membranes, and not only act as a skeleton to provide a platform for protein-protein interactions, but also are involved in signal transduction, nerve regeneration, endocytosis, and lymphocyte activation. Previous studies have shown that flotillins are closely associated with tumor development, invasion, and metastasis. In this article, we review the functions of flotillins in relevant cell processes, their underlying mechanisms of action in a variety of tumors, and their potential applications to tumor molecular diagnosis and targeted therapy.本文旨在对flotillins在相关细胞进程中的作用、在多种肿瘤中的作用和机制及其在肿瘤分子诊断和靶向治疗等方面的潜在应用价值进行综述。图1以示意图的形式直观地展示flotillin-1和flotillin-2的蛋白结构;表1对flotillin-1和flotillin-2在各种肿瘤中的表达异常情况、发挥的生物学功能及其机制进行汇总;在图2中,以模式图的形式展示flotillin-1和flotillin-2在肿瘤细胞中参与的信号通路及导致肿瘤细胞出现的不同表型。许多研究表明,flotillins在多种肿瘤中过表达,并且与肿瘤的发生发展、分期和转移密切相关。转移标志着肿瘤由局部病变发展为不可治愈的系统病变,是肿瘤预后的一个重要影响因素,但是其机制尚未完全阐述。因此,对其机制进行进一步探索有助于促进恶性肿瘤分子诊断、预后和精准治疗的发展。

关 键 词：Flotillins TUMOR Lipid raft protein Signal transduction 

分 类 号：R739.6[医药卫生—肿瘤]